The production of novel sordarin analogues by biotransformation

Journal of Antibiotics

Volumn 54, Issue 11, 2001, Pages 948-957

  Hall, R M ^a   Dawson, M J ^a   Jones, C A ^a   Roberts, A D ^a   Sidebottom, P J ^a   Stead, P ^a   Taylor, N L ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2' O ACETYLSORDARIN; 3 DEFORMYL 3 HYDROXYMETHYL SORDARIN; 4' O DEMETHYLSORDARIN; 6 HYDROXYSORDARICIN; 6 HYDROXYSORDARIN; 7 HYDROXY 4' O DEMETHYLSORDARIN; 7 HYDROXYSORDARICIN; 7 HYDROXYSORDARIN; FUNGAL PROTEIN; GR 135402; SORDARICIN; SORDARICIN 1 GLUCOSE ESTER; SORDARIN 1 GLUCOSE ESTER; SORDARIN 1 METHYL ESTER; SORDARIN 3 CARBOXYLIC ACID; SORDARIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIODIVERSITY; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; FUNGUS CULTURE; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; TAXONOMY;

EID: 0035214037     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.948     Document Type: Article

References (16)

1. New investigational antifungal agents for treating invasive fungal infections
2. Sordarins as antifungal compounds
3. Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition
4. Novel inhibitors of fungal protein synthesis produced by a strain of Graphium putrididis. Isolation, characterisation and biological properties
5. Sordarins: A new class of anti-fungals with selective inhibition of the protein synthesis elongation cycle in yeasts
6. Identification of elongation factor 2 as the essential protein targeted by sordarins in Candida albicans
7. Ribosomal P-protein stalk function is targeted by sordarin
8. Sordarins: In vitro activities of new antifungal derivatives against pathogenic yeasts, Pneumocystis carnii, and filamentous fungi
9. Sordarin antifungal agents
10. Microbial transformation of diterpenes. Hydroxylation of sclareol, manool and derivatives by Mucor plumbeus
11. Microbial metabolism of the diterpene sclareol: Oxidation of the A ring by Septomyxa affinis
12. Bioconversion of grindelic acid into 3α-hydroxygrindelic acid
13. Screening of sordaricin derivatives against endemic fungal pathogens