Reduced excitability of the motor cortex in untreated patients with de novo idiopathic "grand mal" seizures

Journal of Neurology Neurosurgery and Psychiatry

Volumn 71, Issue 6, 2001, Pages 772-776

  Delvaux, V ^a   Alagona, G ^a   Gerard P ^a   De Pasqua, V ^a   Delwaide, P J ^a   Maertens De Noordhout, A ^a  

^a Centre Hospitalier Regional de La Citadelle   (Belgium)

Author keywords

Cortical excitability; Epilepsy; Transcranial magnetic stimulation

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED MUSCLE RESPONSE; EXCITABILITY; FEMALE; GABAERGIC TRANSMISSION; GRAND MAL EPILEPSY; HUMAN; INTERNEURON; MALE; MOTOR ACTIVITY; MOTOR CORTEX; MUSCLE CONTRACTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RECURRENT DISEASE; STIMULUS RESPONSE; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 0035212011     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.71.6.772     Document Type: Article

References (23)

1. Depaulis A, Deransart C, Vergnes M, et al. Mécanismes GABAergiques dans les épilepsies généralisées: Ia dimension neuroanatomique. Rev Neurol (Paris) 1997;153(suppl 1):8-13.
2. Bernard C, Hirsch J, Ben An Y. Récepteurs excitateurs glutamatergiques et épilepsie du lobe temporal. Rev Neurol (Paris) 1997;153(suppl 1):14-24.
3. Bradford HF. Glutamate, GABA and epilepsy. Prog Neurobiol 1995;47:477-511.
4. Vergnes M, Marescaux C, Micheleti G, et al. Enhancement of spike and wave discharges by GABA mimetic drugs in rats with spontaneous petit-mal-like epilepsy. Neurosci Lett 1984;44:912-14.
5. Vergnes M, Boehrer A, Simler S, et al. Opposite effects of GABAB receptor antagonists on absences and convulsive seizures. Eur J Pharmacol 1997;332:245-55.
6. Jefferys JGR. The pathophysiology of epilepsies. In: Laidlaw J, Richens A, Chadwick D, eds. A textbook of epilepsy. Edinburgh: Churchill Livingstone, 1993:241-71.
7. Ziemann U, Steinhoff BJ, Tergau F, et al. Transcranial magnetic stimulation: its current role in epilepsy research. Epilepsy Res 1998;30:11-30.
8. Mavroudakis N, Caroyer JM, Brunko E, et al. Effects of diphenylhydantoin on motor potentials evoked with magnetic stimulation. Electroencephalogr Clin Neurophysiol 1994;93:428-33.
9. Mavroudakis N, Caroyer JM, Brunko E, et al. Effects of vigabatrin on motor potentials with magnetic stimulation. Electroencephalogr Clin Neurophysiol 1997;105:124-7.
10. Ziemann U, Lōnnecker S, Steinhoff BJ, et al. Effects of anti-epileptic drugs on motor cortex excitability in humans: a transcranial magnetic stimulation study. Ann Neurol 1996; 40:367-78.
11. Ziemann U, Lōnnecker S, Paulus W. Inhibition of human motor cortex by ethanol. A transcranial magnetic stimulation study. Brain 1995;118:1437-46.
12. Triggs WJ, Cros D, MacDonell RAL, et al. Cortical and spinal motor excitability during the transcranial magnetic stimulation silent period in humans. Brain Res 1993;628: 39-48.
13. Kujirai T, Caramia MD, Rothwell JC, et al. Cortico-cortical inhibition in human motor cortex. J Physiol (Lond) 1993;471:501-19.
14. Hufnagel A, Elger CE, Marx W, et al. Magnetic motor-evoked potentials in epilepsy: effects of the disease and of anticonvulsant medication. Ann Neurol 1990;28:680-6.
15. Schüler P, Claus D, Stefan H. Hyperventilation and transcranial magnetic stimulation: two methods of activation of epileptiform EEG activity in comparison. J Clin Neurophysiol 1993;10:111-15.
16. Ziemann U, Lōnnecker 5, Steinhoff BJ, et al. The effect of lorazepam on the motor cortex excitability in man. Exp Brain Res 1996;109:127-35.
17. Reutens DC, Berkovic SF, Macdonneil RA, et al. Magnetic stimulation of the brain in generalized epilepsy: reversal of cortical hyperexcitability by anticonvulsants. Ann Neurol 1993:34:351-5.
18. Gianelli M, Cantello R, Civardi C, et al. Idiopathic generalized epilepsy: magnetic stimulation of the motor cortex time-locked and unlocked to 3 Hz spike-and-wave discharges. Epilepsia 1994;35:53-60.
19. Ziemann U, Rothwell JC, Ridding MC. Interaction between intracortical inhibition and facilitation in human motor cortex. J Physiol (Lond) 1996;496:873-81.
20. Brodtmann A, Macdonell RAL, Gilligan AK, et al. Cortical excitability and recovery curve analysis in generalized epilepsy. Neurology 1999;53:1347-9.
21. Caramia MD, Gigli G, Iani C, et al. Distinguishing forms of generalized epilepsy using magnetic brain stimulation. Electroencephalogr Clin Neurophysiol 1996;98:14-19.
22. Brown P, Ridding MC, Werhahn KJ, et al. Abnormalities of the balance between inhibition and excitation in the motor cortex of patients with cortical myoclonus. Brain 1996;119: 309-17.
23. Classen J, Witte OW, Schlaug G, et al. Epileptic seizures triggered directly by focal transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol 1995;94:19-25.