A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease

Annals of Human Genetics

Volumn 65, Issue 5, 2001, Pages 473-482

  Curtis, D ^a   North, B V ^a   Sham, P C ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E;

ALLELE; ALZHEIMER DISEASE; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC MODEL; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; PRIORITY JOURNAL;

EID: 0035211948     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1469-1809.2001.6550473.x     Document Type: Article

References (22)

1. Bertram, L., Blacker, D., Mullin, K., Keeney, D., Jones, J., Basu, S., Yhu, S., McInnis, M. G., Go, R. C., Vekrellis, K., Selkoe, D. J., Saunders, A. J. & Tanzi, R. E. (2000). Evidence for genetic linkage of Alzheimer's, disease to chromosome 10q Science 290, 2302-3.
2. Chalifa-Caspi, V., Prilusky, J. & Lancet, D. (2000). The Unified Database (UDB) http://bioinformatics.weizmann.ac.il/udb. Rehovot, Weizmann Institute of Science.
3. Clerget-Darpoux, F., Bonaiti-Pellie, C. & Hochez, J. (1986). Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42, 393-9.
4. Collins, A., Frezal, J., Teague, J. & Morton, N. E. (1996). A metric map of humans: 23,500 loci in 850 bands. Proc. Natl. Acad. Sci. USA 93, 14771-5.
5. Cordell H. J., Todd, J. A., Bennett, S. T., Kawaguchi, Y. & Farrall, M. (1995). Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes. Am. J. Hum. Genet. 57, 920-34.
6. Cordell, H. J., Wedig, G. C., Jacobs, K. B. & Elston, R. C. (2000). Multilocus linkage tests based on affected relative pairs. Am. J. Hum. Genet. 66, 1273-86.
7. Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E. et al. (1994). Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat. Genet. 7, 180-4.
8. Curtis, D. & Sham, P. C. (1995). Model-free linkage analysis using likelihoods. Am. J. Hum. Genet. 57, 703-16.
9. Curtis, D., Zhao, J. & Sham, P. (1999). Comparison of GENEHUNTER and MFLINK for analysis of COGA linkage data. Genetic Analysis Workshop 11: Analysis of genetic and environmental factors in common diseases.
10. L. Goldin, C. Amos, G. Chase et al. Genet. Epidemiol. 17, S115-S120.
11. Dizier, M. H. & Clerget-Darpoux, F. (1986). Two-disease locus model: sib pair method using information on both HLA and Gm. Genet. Epidemiol. 3, 343-56.
12. Ertekin-Taner, X., Graff-Radford, N., Younkin, L. H., Eckman, C., Baker, M., Adamson, J., Ronald, J., Blangero, J., Hutton, M. & Younkin, S. G. (2000). Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science 290, 2303-4.
13. Kehoe, P., Wavrant-De Vrieze, F., Crook, R., Wu, W. S., Holmans, P., Fenton, I., Spurlock, G., Norton, N., Williams, H., Williams, N., Lovestone, S., Perez-Tur, J., Hutton, M., Chartier-Harlin, M. C., Shears, S., Roehl, K., Booth, J., Van Voorst W., Ramie, D., Williams, J., Goate, A., Hardy, J. & Owen, M. J. (1999). A full genome scan for late onset Alzheimer's disease. Hum. Mol. Genet. 8, 237-45.
14. Lin, S. (2000). Monte Carlo methods for linkage analysis of two-locus disease models. Ann. Hum. Genet. 64, 519-532.
15. Mein, C. A., Esposito, L., Dunn, M. G., Johnson, G. C., Timms, A. E., Goy, J. V., Smith, A. N., Sebag-Montefiore, L., Merriman, M. E., Wilson, A. J., Pritchard, L. E., Cucca, F., Barnett A. H., Bain, S. C. & Todd, J. A. (1998). A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Nat. Genet. 19, 297-300.
16. Myers, A., Holmans, P. & Marshall, H. et al. (2000). Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290, 2304-5.
17. Ott, J. (1991). Analysis of Human Genetic Linkage (revised edition). Baltimore, Johns Hopkins University Press.
18. Risch, N. (1989). Linkage detection tests under heterogeneity. Genet. Epidemiol. 6, 473-80.
19. Schork, N. J., Boehnke, M., Terwilliger, J. D. & Ott, J. (1993). Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am. J. Hum. Genet. 53, 1127-36.
20. Sham, P., Zhao, J. & Curtis, D. (2000). Power comparison of parametric and non-parametric linkage tests in small pedigrees. Am. J. Jum. Genet. 66, 1661-8.
21. Smyth, C., Kalsi, G., Curtis, D., Brynjolfsson, J., O'Neill, J., Rifkin, L., Moloney, E., Murphy, P., Petursson, H. & Gurling, H. (1997). Two-locus admixture linkage analysis of bipolar and unipolar affective disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22. Genomics 39, 271-8.
22. Tienari, P. J., Terwilliger, J. D., Ott, J., Palo, J. & Peltonen, L. (1994). Two-locus linkage analysis in multiple sclerosis (MS). Genomics 19, 320-5.