Vasoactive intestinal peptide has a direct positive inotropic effect on isolated human myocardial trabeculae

Clinical Science

Volumn 101, Issue 6, 2001, Pages 637-643

  Saetrum Opgaard, O ^a   Knutsson, M ^a   De Vries, R ^a   Tom, B ^a   Saxena, P R ^a   Edvinsson, L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Inotropic agents; PAC1 receptor; Vasoactive intestinal peptide; VPAC1 receptor, VPAC2 receptor

Indexed keywords

MESSENGER RNA; PAC1 RECEPTOR; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2; VASOACTIVE INTESTINAL POLYPEPTIDE[6-28];

ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HEART ATRIUM MUSCLE; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE WALL; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; INOTROPISM; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADOLESCENT; ADULT; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; FEMALE; HEART; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; PEPTIDE FRAGMENTS; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0035211845     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20010076     Document Type: Article

References (34)

1. Distribution of vasoactive intestinal polypeptide-like immunoreactivity in the mammalian heart. Interrelation with neurotensin- and substance P-like immunoreactive nerves
2. Innervation and effects of vasoactive substances in the coronary circulation
3. Release of vasoactive intestinal peptide and neuropeptide Y from canine heart
4. Vagal stimulation during muscarinic and beta-adrenergic blockade increases atrial contractility and heart rate
5. Vagal nerve stimulation during muscarinic and beta-adrenergic blockade causes significant coronary artery dilation
6. Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate
7. Vagal nerve stimulation releases vasoactive intestinal peptide which significantly increases coronary artery blood flow
8. Vasoactive intestinal peptide: Cardiovascular effects
9. Cardiovascular effects of vasoactive intestinal peptide in healthy subjects
10. Effect of vasoactive intestinal polypeptide (VIP) on pulmonary ventilation-perfusion relationships and central haemodynamics in healthy subjects
11. Influence of vasoactive intestinal polypeptide (VIP) on splanchnic and central hemodynamics in healthy subjects
12. Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology
13. Contractile effects of cardiac neuropeptides in isolated canine atrial and ventricular muscles
14. Desensitization of myocardial but not coronary VIP receptor-mediated responses in dogs
15. Cardiac responses to VIP and VIP-ergic-cholinergic interaction in isolated dog heart preparations
16. The in vitro chronotropic and inotropic effects of vasoactive intestinal peptide (VIP) on the atria and ventricular papillary muscle from Cynomolgus monkey heart
17. Inotropic effects of calcitonin gene-related peptide, vasoactive intestinal polypeptide and somatostatin on the human right atrium in vitro
18. Vasoactive intestinal peptide receptor in failing human ventricular myocardium exhibits increased affinity and decreased density
19. Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor
20. Cloning and functional characterization of the human vasoactive intestinal peptide (VIP)-2 receptor
21. Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor
22. Pituitary, adenylate cyclase-activating polypeptide and its receptors: From structure to functions
23. Development of helix-based vasoactive intestinal peptide analogues: Identification of residues required for receptor interaction
24. Effect of preservation solution on results of cadaveric kidney transplantation
25. Different pharmacological responses of atrium and ventricle: Studies with human cardiac tissue
26. Vasoactive intestinal peptide in canine hearts: Effect of total cardiac denervation
27. Direct coronary vasodilation induced by intracoronary vasoactive intestinal peptide
28. Human and canine ventricular vasoactive intestinal polypeptide: Decrease with heart failure
29. Multiple human receptors for pituitary adenylyl cyclase-activating polypeptide and vasoactive intestinal peptide are expressed in a tissue-specific manner
30. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide
31. Positive inotropy mediated via CGRP receptors in isolated human myocardial trabeculae
32. B receptors in human myocardial trabeculae
33. Atrial fibrillation is associated with a lower exercise capacity in male chronic heart failure patients
34. Effects of enalapril on vasoactive intestinal peptide metabolism and tissue levels