Antioxidants inhibit cytokine production and suppress NF-κB activation in CAPAN-1 and CAPAN-2 cell lines

Digestive Diseases and Sciences

Volumn 46, Issue 12, 2001, Pages 2768-2772

  Blanchard, John A ^a   Barve, Shirish ^a   Joshi Barve, Swati ^a   Talwalker, Ramesh ^a   Gates, Lawrence L K ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Acute pancreatitis; Antioxidants; Chronic pancreatitis; Interleukin 6; Interleukin 8; NF B; Pancreatic adenocarcinoma

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; BUTYLATED HYDROXYANISOLE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; OXYTETRACYCLINE;

ACUTE PANCREATITIS; ARTICLE; CANCER CELL CULTURE; CAPAN 1 CELL; CAPAN 2 CELL; CHRONIC PANCREATITIS; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL;

ADENOCARCINOMA; ANTIOXIDANTS; BUTYLATED HYDROXYANISOLE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; NF-KAPPA B; PANCREATIC NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0035211278     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012795900871     Document Type: Article

References (22)

1. Endotoxaemia and serum tumor necrosis factor as prognostic markers in severe acute pancreatitis
2. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis
3. Increased monocyte cytokine production in association with systemic complications in acute pancreatitis
4. Serum interleukin-6 in acute pancreatitis due to common bile duct stones. A reliable marker of necrosis
5. Interleukin 6 is a useful marker for early prediction of the severity of acute pancreatitis
6. Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis
7. Serum interleukin-6, interleukin-8, and beta 2-microglobulin in early assessment of severity of acute pancreatitis. Comparison with serum C reactive protein
8. Interleukins and their antagonists but not TNF and its receptors are released in post-ERCP pancreatitis
9. Differential expression of chemokines in normal pancreas and in chronic pancreatitis
10. Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia
11. Cytokine production by CAPAN-1 and CAPAN-2 cell lines
12. Constitutive and inducible interleukin-8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic
13. Effect of interleukin-8 on production of tumor-associated substances and autocrine growth of human liver and pancreatic cancer cells
14. Interleukin (IL)-6 as a pancreas carcinoma-derived vascular permeability regulator in vitro
15. Portal but not peripheral serum levels of interleukin 6 could interfere with glucose metabolism in patients with pancreatic cancer
16. A framework for the aetiogenesis of chronic pancreatitis
17. Placebo-controlled trials of antioxidant therapy including S-adenosyl methionine in patients with recurrent non-gallstone pancreatitis
18. Micronutrient antioxidant therapy in the nonsurgical management of painful chronic pancreatitis: Longterm observations
19. Oxygen radicals and a long-term antioxidant therapy in chronic pancreatitis patients
20. Multiple nuclear factors interact with the immunoglobulin enhancer sequences
21. Accurate transcription initiation of RNA polymerase II in a soluble extract from isolated mammalian nuclei
22. Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squanous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines