Synthesis of ellipticine by hetaryne cycloadditions - Control of regioselectivity

European Journal of Organic Chemistry

Volumn , Issue 23, 2001, Pages 4543-4549

  Díaz, Maite ^a   Cobas, Agustín ^a   Guitián, Enrique ^a   Castedo, Luis ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Antitumor agents; Arynes; Cycloadditions

Indexed keywords

ELLIPTICINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL MUTANT; CHEMICAL ANALYSIS; HYDROGENATION; PHOSPHORYLATION; SYNTHESIS;

EID: 0035211203     PISSN: 1434193X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-0690(200112)2001:23<4543::aid-ejoc4543>3.0.co;2-%23     Document Type: Article

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42. Reaction times of around 24 h are typical, except for cycloadditions of 2-fluoro-3,4-didehydropyridine (4c), which reacts in approx. 4 h. However, it is advisable to work up the reactions as soon as the starting diene is consumed (TLC monitoring), especially in the case of adducts of pyrroloindole 6, which are not very stable under the reaction conditions.