Modulation of CD4 T cell function by soluble MHC II-peptide chimeras

International Reviews of Immunology

Volumn 20, Issue 5, 2001, Pages 547-573

  Casares, S ^a   Bona, C A ^a   Brumeanu, T D ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

CD4 T cells; Immunospecific modulation; Soluble MHC II peptide chimeras

Indexed keywords

AMINO ACID; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; CELL FUNCTION; CELL STIMULATION; CHIMERA; IMMUNITY; LIGAND; MAJOR HISTOCOMPATIBILITY COMPLEX; SIGNAL TRANSDUCTION; SOLUBILITY; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR;

EID: 0035211041     PISSN: 08830185     EISSN: None     Source Type: Journal    
DOI: 10.3109/08830180109045578     Document Type: Review

References (101)

1. The law of mass action governs antigen-stimulated cytolytic activity of CD8 cytotoxic T lymphocytes
2. Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity
3. T cell positive selection by a high density, low affinity ligand
4. Evidence for a different avidity model of T cell selection in the thymus
5. Antigen-analog histocompatibility complexes act as antagonists of the T cell receptor
6. Regulation of the immune response to peptide antigens: Differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype
7. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling
8. The T lymphocyte response to cytochrome c. IV. Distinguishable sites on a peptide antigen which affect antigenic strength and memory
9. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand
10. High- and low-potency ligands with similar affinities for the TCR: The importance of kinetics in TCR signaling
11. The dynamics of T cell receptor signaling: Complex orchestration and the key roles of tempo and cooperation
12. Kinetics proofreading in T cell receptor signal transduction
13. Kinetic discrimination in T cell activation
14. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates tan agonists
15. Ligand recognition by T cell receptors
16. Ligand-specific oligomerization of T cell receptor molecules
17. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
18. The immunological synapse: A molecular machine controlling T cell activation
19. Localization, quantitation and in sítu detection of specific peptide-MHC class I complexes using a monoclonal antibody
20. Characterization and quantification of peptide-MHC complexes produced from egg lysozyme using a monoclonal antibody
21. Recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells
22. T cell receptor-MHC class I peptide interactions: Affinity, kinetics, and specificity
23. k complexes: Correlation of the dissociation rate with T cell responsiveness
24. Binary and ternary complexes between T cell receptor, class II MHC and superantigen in vitro
25. Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR
26. CD28 enhances formation of stable T cell receptor/MHC class I molecule complexes
27. T cell receptor affinity and thymocyte positive selection
28. + peptide recognition
29. Low affinity interaction of peptide-MC complexes with T cell receptor
30. Specific low-affinity recognition of major histocompatibility complexes plus peptide by soluble T cell receptor
31. Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes
32. High-affinity reactions between antigen-specific T cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins
33. CD8 modulation of T cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes
34. d-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative
35. The specificity and orientation of a TCR to its peptide-MC class II ligands
36. Relationship to the T3 molecular complex
37. Crystal structure of a T cell receptor beta-chain complexed with superantigen
38. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen
39. Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B
40. The crystal structure of a T cell receptor in complex with peptide and MHC class II
41. Crystal structure of HLA-DR2 (DRA* 0101, DRB1* 1501) complexed with a peptide from human myelin basic protein
42. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
43. Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
44. Human immunodeficiency virus gp120 binding C′C″ ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules
45. Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding
46. HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4
47. MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8
48. A soluble CD4 protein selectively inhibits HIV replication and syncytium formation
49. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains
50. Molecular characteristics of an HIV-binding recombinant fragment of human CD4
51. Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals
52. Three-dimensional structure of the human class II major histocompatibility antigen HLA-DR1
53. Regulation of T helper-Blymphocyte adhesion through CD4-HLA class II interaction
54. Purified β-chain of MHC class II binds to CD4 molecules on transfected HeLa cells
55. Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules
56. The structural basis of CD4-MHC class II onteractions: Coreceptor contributions to T cell receptor antigen recognition and oligomerization-dependent signal transduction
57. Three-dimensional segregation of supramolecular activation clusters in T cells
58. Differential clustering of CD4 and CD3 zeta during T cell recognition
59. Production of soluble MHC class II proteins with covalently bound peptides
60. Engineering and characterization of a murine MHC class II-Immunoglobulin chimera expressing an immunodominant CD4 T viral epitope
61. Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: The role of CD4 coreceptor
62. Kinetics of T cell receptor binding by bivalent HLA-DR/peptide complexes that activate antigen-specific human T cells
63. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
64. The relationship of MHC-peptide binding and T cell activation probed with chemically defined MHC class II oligomers
65. Enzymatically mediated engineering of multivalent MHC II-peptide chimeras
66. Initiation of signal transduction through the T cell receptor requires multivalent engagement of peptide/MHC ligands
67. A diverse set of oligomeric class II MHC-peptide complexes for probing T cell receptor interactions
68. Antigen-specific signaling by a soluble, dimeric peptide/MHC Class II/Fc chimera leading to Th2 differentiation
69. T cell tolerance and autoimmune diabetes
70. Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands
71. Understanding the mechanisms of sustained signaling and T cell activation
72. Antigen-specific down-regulation of T cells by doxorubicin delivered by MHC II-peptide chimeras
73. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
74. Novel CD4 and CD8 T cell subsets
75. Role of Th1 and Th2 cells in bacterial infections
76. The Th1/Th2 paradigm
77. Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a Th2 phenomenon?
78. Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones
79. Molecular regulation of cytokine gene expression during the immune response
80. Signaling and transcription in T helper development
81. Impaired IL-12 responses and enhanced development of Th2 cells in STAT4-deficient mice
82. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
83. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase
84. A family of cytokine-inducible inhibitors of signaling
85. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
86. Models of T cell anergy: Is there a common molecular mechanism?
87. Following the development of a CD4 T cell response in vivo: From activation to memory formation
88. Transcriptional control of cytokine genes
89. Re1A/p65 is a molecular target for the immunosuppressive action of protein kinase A
90. Transcriptional regulation of T lymphocyte development and function
91. On the various manifestations of spontaneous diabetes in rodent models
92. Variable effects of transgenic c-Maf on autoimmune diabetes
93. Prevention of diabetes in NOD mice treated with antibody to murine IFN-gamma
94. Antigen-specific deletion of cloned T cells using peptide-toxin conjugate complexed with purified class II major histocompatibility complex antigen
95. MHC interaction and T cell recognition of carbohydrates and glycopeptides
96. Enzymatically mediated, glycosidic conjugation of immunoglobulins with viral epitopes
97. Adriamycin. A new anticancer drug with significant clinical activity
98. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II
99. Decreased CP-1 (NF-Y) activity results in transcriptional down-regulation of topoisomerase IIα in a doxorubicin-resistant variant of human multiple myeloma RPMI 8226
100. Cell surface actions of adriamycin