Estimation of absorption rate of α-human atrial natriuretic peptide from the plasma profile and diuretic effect after intranasal administration to rats

Biopharmaceutics and Drug Disposition

Volumn 22, Issue 4, 2001, Pages 137-146

  Miyamoto, Misao ^a   Tsukune, Tadashi ^a   Hori, Seiichi ^a   Hayashi, Teruaki ^a   Natsume, Hideshi ^a   Sugibayashi, Kenji ^a   Morimoto, Yasuori ^a  

^a JOSAI UNIVERSITY   (Japan)

Author keywords

Nasal absorption; PK model; PK PD model; Rat; hANP; human atrial natriuretic peptide

Indexed keywords

ATRIAL NATRIURETIC FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CALCULATION; COMPARTMENT MODEL; CONTROLLED STUDY; DIURESIS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG EXCRETION; DRUG POTENCY; HOMEOSTASIS; HYPOTENSION; HYSTERESIS; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; RAT; SIMULATION;

ABSORPTION; ADMINISTRATION, INTRANASAL; ALGORITHMS; ANIMALS; ATRIAL NATRIURETIC FACTOR; DIURETICS; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; MALE; MODELS, BIOLOGICAL; NASAL MUCOSA; RATS; RATS, WISTAR;

EID: 0035210974     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.272     Document Type: Article

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