Assessment of water and sediment contamination in small streams by means of cytological and biochemical alterations in isolated rainbow trout (Oncorhynchus mykiss) hepatocytes

Journal of Aquatic Ecosystem Stress and Recovery

Volumn 8, Issue 3-4, 2001, Pages 337-354

  Braunbeck, Thomas ^a   Strmac, Marija ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Biochemistry; Cytopathology; Fish; Hepatocytes; In vitro exposure; Metabolic enzymes; Mixture contamination; Sediment toxicity; Ultrastructure

Indexed keywords

ACETONE; ACID PHOSPHATASE; ALANINE AMINOTRANSFERASE; CATALASE; LACTATE DEHYDROGENASE; PEROXISOME PROLIFERATOR; PESTICIDE; POLYCHLORINATED BIPHENYL; POLYCYCLIC AROMATIC HYDROCARBON;

SEDIMENT POLLUTION; WATER POLLUTION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CELL NUCLEUS MEMBRANE; CELL PROLIFERATION; CELL STRUCTURE; CELL VACUOLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPATHOLOGY; CYTOSOL; CYTOTOXICITY; DOSE RESPONSE; ELECTRON MICROSCOPY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVATION; ENZYME ASSAY; GERMANY; GLYCOLYSIS; HETEROCHROMATIN; LIVER CELL; LIVER MITOCHONDRION; LIVER TOXICITY; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN METABOLISM; RAINBOW TROUT; ROUGH ENDOPLASMIC RETICULUM; SEDIMENT; TIME; WATER CONTAMINATION; WATER SAMPLING;

ANIMALIA; MYKISS; ONCORHYNCHUS MYKISS; SALMONIDAE;

EID: 0035210867     PISSN: 13861980     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012906810086     Document Type: Article

References (125)

1. Physicochemical and morphological characterization of two small polluted streams in southwest Germany
2. Biotests an Sedimenten
3. Biologisches Bewertungskonzept für Sedimente
4. Oxidative and conjugative metabolism in isolated rainbow trout liver cells
5. Cytochrome P-450-dependent metabolism in isolated liver cells from fed and starved rainbow trout, Salmo gairdneri
6. Spectral properties of substrate-cytochrome P-450 interaction and catalytic activity of xenobiotic metabolizing enzymes in isolated rainbow trout liver cells
7. Oxidative and conjugative metabolism of xenobiotics in isolated liver cells from thermally acclimated rainbow trout
8. Disulfoton as a major toxicant in the chemical spill at Basel in November 1986: Acute and chronic studies with eel and rainbow trout
9. Simultaneous exposure of fish to endosulfan and disulfoton in vivo: Ultrastructural stereological and biochemical reactions in hepatocytes of male rainbow trout (Oncorhynchus mykiss)
10. A fish hepatocyte model for the investigation of the effects of environmental contaminants
11. Review - Isolated fish hepatocytes - Model systems for toxicology research
12. Altered plasma membrane ion permeability in mercury-induced cell injury: Studies in hepatocytes of elasmobranch Raja erinacea
13. Intracellular distribution of monoamino oxidase, aspartate aminotransferase, alanine aminotransferase, D-amino acid oxidase and catalase in rat liver tissue
14. Induction of cytochrome P450 1A and DNA damage in isolated rainbow trout (Oncorhynchus mykiss) hepatocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin
15. Isolated hepatocytes - Preparation, properties and application
16. High yield preparation of isolated rat liver parenchymal cells
17. Isolated trout liver cells: Establishing short-term primary cultures exhibiting cell-to-cell interactions
18. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
19. Umweltcytologie - Zelluläre Reaktionen zum Nachweis einer Schadstoffbelastung von Organismen
20. Cytological alterations in isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) exposed in vitro to 4-chloroaniline
21. Detection of environmental relevant pesticide concentrations using cytological parameters: Pesticide specificity in the reaction of rainbow trout liver?
22. Zelltests in der Ökotoxikologie - Cytotoxizitätstests mit Zellkulturen aus Fischen als Alternative und Ergänzung zu konventionellen Fischtests
23. Cytological alterations in fish hepatocytes - In vivo and in vitro biomarkers of environmental contamination
24. Senescence of hepatocytes isolated from rainbow trout (Oncorhynchus mykiss) in primary culture - An ultrastructural study
25. Induction of biotransformation in the liver of Eel (Anguilla anguilla L.) by sublethal exposure to dinitro-ø-cresol: An ultrastructural and biochemical study
26. Toxicant-induced cytological alterations in fish liver as biomarkers of environmental pollution? A case-study on hepatocellular effects of dinitro-ø-cresol in golden ide (Leuciscus idus melanotus)
27. Sex-specific reaction of liver ultrastructure in zebra fish (Brachydanio rerio) after prolonged sublethal exposure to 4-nitrophenol
28. Liver pathology in eels (Anguilla anguilla L.) from the Rhine river exposed to the chemical spill at Basle in November 1986
29. Hepatic steatosis in zebrafish (Brachydanio rerio) induced by long-term exposure to γ-hexachlorocyclohexane
30. Species-specific reaction of liver ultrastructure of zebra fish (Brachydanio rerio) and trout (Salmo gairdneri) after prolonged exposure to 4-chloroaniline
31. Regenbogenforelle and Zebrabärbling, zwei Modelle für verlängerte Toxizitätstests: Relative Empfindlichkeit, Art-und Organspezifitaet in der cytopathologischen Reaktion von Leber und Darm auf Atrazin
32. Ultrastructural alterations in hepatocytes of medaka (Oryzias latipes) during the cytotoxic phase of diethylnitrosamine
33. Primärzellkulturen aus Fischhepatocyten als alternatives Testsystem in der ökotoxiko-logischen Forschung
34. Mixed function oxygenases in cultured fish cells: Contributions of in vitro studies to the understanding of MFO induction
35. Extracts from settling particulate matter collected in the Stockholm archipelago waters: Embryolethality, immunotoxicity, and EROD-inducing potency of fractions containing aliphatics/monoaromatics, diaromatics, or polyaromatics
36. Microsomal lipid oxidation
37. Assessing the toxicity of freshwater sediments
38. Sediment toxicity testing issues and methods
39. Lipid peroxidation and its role in toxicology
40. Preliminary comparison of sediment extraction procedures and exchange solvents for hydrophobic compounds based on inhibition of bioluminescence
41. Changes in the blood of the brown bullhead (Ictalurus nebulosus LeSueur) following short- and long-term exposure to copper (II)
42. N-Nitrosodiethylamine-induced hepatocarcinogenesis in estuarine shipshead minnow (Cyprinodon variegatus): Neoplasms and related lesions compared with mammalian lesions
43. Comparative activation of aflatoxin B1 to mutagens by isolated hepatocytes from rainbow trout (Salmo gairdneri) and coho salmon (Oncorhynchus kisutch)
44. Toxicity of cadmium, copper, and mercury to isolated trout hepatocytes
45. Biochemical mechanisms: Metabolism, adaptation and toxicity
46. Mechanisms and biological relevance of lipid peroxidation initiation
47. Isolation and subfractionation on Ficoll gradients of adult rat hepatocytes
48. Cytochrome p450IA induction by coplanar PCB, a PAH mixture, and PCB-contaminated sediment extracts following microinjection of rainbow trout sac-fry
49. Toxic potencies of lipophilic extracts from sediments and settling particulate matter (SPM) collected in a PCB contaminated river system
50. Comparison of anesthetic potency of benzocaine hydrochloride and MS-222 in two freshwater fish species
51. Comparative studies on isolated rat hepatocytes and AS-30D hepatoma cells with leucoidin from Pseudomonas aeruginosa
52. A novel mixed hepatocyte-fibroblast culture system and its use as a testfor metabolism-mediated cytotoxicity
53. Evaluation of the genotoxicity of Environmental contaminants in sediments to rainbow trout hepatocytes
54. Available intracellular Zn as a potential indicator of heavy metal exposure in rainbow trout hepatocytes
55. Metallothionein induction and metal homeostasis in rainbow trout hepatocytes exposed to mercury
56. Lethal and sublethal effects of marine sediment extracts on rainbow trout hepatocytes
57. Short- and long-term effects of copper on the rosy barb (Puntius conchonius Ham.)
58. Mechanisms of anti-carcinogenesis by indole-3-carbinol: Effect on the distribution and metabolism of aflatoxin B1 in rainbow trout
59. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
60. Comparison of whole-sediment, elutriate and pore-water exposures for use in assessing sediment-associated organic contaminants in bioassays
61. The effects of xenobiotics on fish tissues: Morphological studies
62. Recent applications of fish cell culture to biomedical research
63. Liver structural alterations accompanying chronic toxicity in fishes: Potential biomarkers of exposure
64. PCB-induced alterations in teleost liver: A model for environmental disease in fish
65. Normal versus abnormal structure: Considerations in morphologic responses of teleost to pollutants
66. Cytological changes during progression of neoplasia in selected fish species
67. Cellular composition and ultrastructure of hepatic neoplasms induced by diethyl-nitrosamine in Oryzias latipes
68. Physical and chemical parameters of sediment extraction and fractionation that influence toxicity as evaluated by Microtox
69. Chemical analyses in small streams: Results of a four year monitoring (Valimar, 1995-1998)
70. Chemical analyses of water, sediment and biota in two small streams in southwest Germany
71. Maintenance of differentiated rat Hepatocytes in primary culture
72. Isolated mammalian hepatocytes in culture
73. Use of ferrocyanide-reduced osmium tetroxide in electron microscopy
74. Copper-induced hepatic ultrastructural alterations in the snake-headed fish, Channa punctatus
75. Principles of toxicology
76. Establishment of fish hepatocyte cultures for use in vitro carcinogenicity studies
77. Trout hepatocyte culture: Isolation and primary culture
78. Use of trout serum to prepare primary attached monolayer cultures of hepatocytes from rainbow trout (Salmo gairdneri)
79. Cytotoxicity/genotoxicity: The application of cell culture techniques to the measurement of marine sediment pollution
80. Cytotoxicity phase of diethylnitrosamine-induced hepatic neoplasia in medaka
81. Hepatic cellular distribution of cytochrome CYP 1A in rainbow trout (Oncorhynchus mykiss): An immunohisto- and cytochemical study
82. Comparison of acute response to PCB in livers of rat and channel catfish. A biochemical and morphologic study
83. Comparison of trout hepatocyte culture on different substrates
84. Antioxidant enzymes in liver of dab Limanda limanda from the North Sea
85. Pro-oxidant, antioxidant and 7-ethoxyresorufin O-deethylase (EROD) activity responses in liver of dab (Limanda limanda) exposed to sediment contaminated with hydrocarbons and other chemicals
86. Metabolism and DNA binding of aflatoxicol and aflatoxin B1 in vivo and in isolated hepatocytes from rainbow trout (Salmo gairdneri)
87. Rainbow trout and human cells in culture for the evaluation of the toxicity of aquatic pollutants: A study with cadmium
88. Rainbow trout and human cells in culture for the evaluation of the toxicity of aquatic pollutants: A study with lead
89. Two experimental methods to determine the speciation of cadmium in sediment from the river Neckar
90. Oxidant, mixed-function oxidase and peroxisomal responses in channel catfish to a bleached kraft mill effluent
91. Evaluation of cytotoxicity in cultured cells by enzyme leakage
92. Fish hepatocytes: A model metabolic system
93. Alanine aminotransferase
94. Acid phosphatases - Orthophosphoric monoester phosphohydrolase
95. Cytopathology of liver and kidney in rainbow trout (Oncorhynchus mykiss) after long-term exposure to sublethal concentrations of linuron
96. Alterations in the synthesis of proteins in the hepatocytes of rainbow trout fed cyclopropenoid acids
97. The isolated hepatocyte: Use in toxicology and xenobiotic biotransformations
98. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy
99. Biochemical and genetic indices of marine pollution in Spanish littoral
100. Promutagen activation by fish liver as a biomarker of littoral pollution
101. Metabolic activation of carcinogenic aromatic amines by fish exposed to environmental pollutants
102. Peroxisome proliferator activated receptors in Atlantic salmon (Salmo salar): Effects on PPAR transcription and acyl-CoA oxidase activity in hepatocytes by peroxisome proliferators and fatty acids
103. Changes in catalase, glutathione peroxidase and glutathione-S-transferase activities in the liver of newts exposed to 2-methyl-4-chlorophenoxyacetic acid (MCPA)
104. Evaluation of a rodent peroxisome proliferator in two species of freshwater fish: Rainbow trout (Oncorhynchus mykiss) and Japanese medaka (Oryzias latipes)
105. Brown trout (Salmo trutta f. fario) liver ultrastructure as a biomarker for assessment of small stream pollution
106. Isolation and primary culture of teleost hepatocytes
107. Cellular response profile to chemical stress
108. Metabolism and DNA adduct formation of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in fish cell lines in culture
109. A low viscosity embedding medium for electron microscopy
110. Ultrastructural changes in isolated rat hepatocytes after incubation with carbon tetrachloride
111. Isolated hepatocytes of rainbow trout (Oncorhynchus mykiss) as a tool to discriminate between differently contaminated small river systems
112. Induction of heat shock proteins, changes in liver ultrastructure, and alterations of fish behavior: Are these biomarkers related and are they useful to reflect the state of pollution in the field?
113. The project VALIMAR (VALIdation of bioMARkers for the assessment of small stream pollution): Objectives, experimental design, summary of results, and recommendations for the application of biomarkers in risk assessment
114. Relationships between microtox test results, extraction methods, and physical and chemical compositions of marine sediment samples
115. Intestinal glutathione S-transferase activity in flounder Platichthys flesus collected from contaminated and reference sites
116. Evaluation of microsomal and cytosolic biomarkers in a seven-day trout sediment toxicity test
117. DNA repair synthesis following exposure to chemical mutagens in primary liver, stomach, and intestinal cells isolated from rainbow trout
118. Liver DNA bound in vivo with aflatoxin B1 as a measure of hepatocarcinoma initiation in rainbow trout
119. Induction of peroxisome proliferation in rainbow trout exposed to ciprofibrate
120. Isolated fish hepatocytes as a tool in aquatic toxicology-sublethal effects of dinitro-ø-cresol and 2,4-dichlorophenol
121. Isolated fish hepatocytes as a tool in aquatic toxicology-experiments with dinitro-ø-cresol and 2,4-dichlorophenol
122. Cytologic evidence for malachite green toxicity in isolated rainbow trout (Oncorhynchus mykiss) hepatocytes
123. Cytological alterations in fish fibrocytic R1 cells as an alternative test system for the detection of sublethal effects of environmental pollutants: A case-study with 4-chloroaniline
124. Acute and sublethal toxicity of seepage water from garbage dumps to permanent cell lines and primary cultures of hepatocytes from rainbow trout (Oncorhynchus mykiss): A novel approach to environmental risk chemicals and chemical mixtures
125. Cytological and biochemical response of R1 cells and isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) to subacute in vitro exposure to disulfoton