Prednisolone-appended α-cyclodextrin: Alleviation of systemic adverse effect of prednisolone after intracolonic administration in 2,4,6-trinitrobenzenesulfonic acid-induced colitis rats

Journal of Pharmaceutical Sciences

Volumn 90, Issue 12, 2001, Pages 2103-2112

  Yano, Hideki ^a   Hirayama, Fumitoshi ^a   Arima, Hidetoshi ^a   Uekama, Kaneto ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Antiinflammatory effect; Prednisolone; Prednisolone appended cyclodextrin; Systemic adverse effect

Indexed keywords

ALPHA CYCLODEXTRIN; MYELOPEROXIDASE; PREDNISOLONE; PREDNISOLONE HEMISUCCINATE; TRINITROBENZENESULFONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON INJURY; CONTROLLED STUDY; COVALENT BOND; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HYDROLYSIS; ENZYME ACTIVITY; MALE; NONHUMAN; RAT; SCORING SYSTEM; SLOW DRUG RELEASE;

EID: 0035209965     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1161     Document Type: Article

References (26)

1. Intensive intravenous regimen for severe attacks of ulcerative colitis
2. High dose methylprednisolone in treatment of active ulcerative colitis
3. Medical therapy in ulcerative colitis
4. A controlled trial of beclomethasone versus betamethasone enemas distalulcerative colitis
5. Treatment of distal ulcerative colitis (proctosigmoiditis) in relapse: Comparison of hydrocortisone enemas and rectal hydrocortisone foam
6. Cyclodextrins: Their future in drug formulation and delivery
7. Cyclodextrin drug carrier systems
8. Effect of bile on the intestinal absorption of αcyclodextrin in rats
9. Enzymatic degradation of α- and β-cyclodextrins by bacteroides of the human colon
10. Biopharmaceutical evaluation of maltosyl-β-cyclodextrin as a parenteral drug carrier
11. The pharmacokinetics of β-cyclodextrin and hydroxypropyl-β-cyclodextrin in the rat
12. Pharmacoknetic analysis of 6-monoamino-β-cyclodextrin after intravenous or oral administration to rats using a specific enzyme immunoassay
13. A new specific enzyme immunoassay allowing an efficient pharmacokinetic evaluation of γ-cyclodextrin after intravenous administration to rats
14. Hydrolysis behavior of prednisolone 21-hemisuccinate/β-cyclodextrin amide conjugate: Involvement of intramolecular catalysis of amide group in drug release
15. Preparation of prednisolone-appended α-, β-, and γcyclodextrins: Substitution at secondary hydroxyl groups and in vitro hydrolysis behavior
16. Hapten-induced model of chronic inflammation and ulceration in the rat colon
17. Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzensulfonic acid-induced colitis in rats
18. Dietary fish oil reduces progression of chronic inflammatory lesion in a rat model of granulomatous colitis
19. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker
20. Quantitative assay for acute intestinal inflammation based on myeroperoxydase activety
21. A[[(4-biphenylyl)acetyl] amino] -α-, -β-and -γ-cyclodextrins: Potential prodrugs for colonspecific delivery
22. ®
23. Local antiinflammatory activity and systemic side effect of NM-135, a new prodrug glucocorticoid, in an experimental inflammatory rat model
24. Colon-specific drug delivery based on a cyclodextrin prodrug: Release behavior of biphenylylacetic acid from its cyclodextrin conjugates in rat intestinal tracts after oral administration
25. Release characteristics of a short-chain fatty acid, n-butyric acid, from its β-cyclodextrin ester conjugate in rat biological media