Physicochemical study of the solid forms of a new drug

Journal of Pharmaceutical Sciences

Volumn 90, Issue 12, 2001, Pages 2131-2140

  Marini, A ^a   Berbenni, V ^a   Bruni, G ^a   Margheritis, C ^a   Orlandi, A ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b GSK   (Italy)

Author keywords

Dehydration; Hydrates; Polymorphism; Thermal methods; Thermodynamics

Indexed keywords

2 INDOLECARBOXYLIC ACID; GAVESTINEL;

ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CRYSTALLIZATION; DEHYDRATION; DRUG FORMULATION; DRUG STABILITY; DRUG STRUCTURE; ENTHALPY; HYDRATION; HYSTERESIS; MOLECULAR MODEL; NEUROTOXICITY; PHASE TRANSITION; PHYSICAL CHEMISTRY; THERMAL ANALYSIS; THERMODYNAMICS; THERMOGRAVIMETRY;

EID: 0035209947     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1164     Document Type: Article

References (7)

1. Characterization of habits and crystalline modification of solids and their pharmaceutical applications
2. Pharmaceutical hydrates
3. Characterization of humidity-dependent changes in crystal properties of a new HMG-CoA reductase inhibitor in support of its dosage form development
4. Phase transformations and stabilization of metastable states of molecular crystals under mechanical activation
5. Indole-2carboxylic acid derivatives
6. Determination of water content in pharmaceutical hydrates by differential scanning calorimetry