Effect of sea anemone toxin anthopleurin-Q on sodium current in guinea pig ventricular myocytes

Acta Pharmacologica Sinica

Volumn 22, Issue 12, 2001, Pages 1107-1112

  Li Ying, F ^a   Yang, L ^a   Lan, C ^a   Hong Yi, Z ^a   Wei Xing, Y ^a   Guo Jin, X ^a   Ming Xing, J ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Myocardium; Patch clamp techniques; Sea anemone; Sodium current; Toxins

Indexed keywords

ANTHOPLEURIN Q; SEA ANEMONE TOXIN; SODIUM CHANNEL; SODIUM ION; UNCLASSIFIED DRUG; ANTHOPLEURIN A; ANTHOPLEURIN-A; MARINE TOXIN; PEPTIDE;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; FEMALE; GUINEA PIG; HEART MUSCLE CELL; HEART VENTRICLE WALL; MALE; NONHUMAN; PATCH CLAMP; SEA ANEMONE; SODIUM CURRENT; ANIMAL; CHEMISTRY; CYTOLOGY; ELECTROPHYSIOLOGY; HEART VENTRICLE; METABOLISM; SODIUM CHANNEL;

ANIMAL; ELECTROPHYSIOLOGY; FEMALE; GUINEA PIGS; HEART VENTRICLE; MALE; MARINE TOXINS; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PEPTIDES; SEA ANEMONES; SODIUM CHANNELS;

EID: 0035206447     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Purification of three polypeptides with neuro- and cardio-toxic activity from the sea anemone: Anemonia sulcata
2. Potential-dependent action of anemonia sulcata toxins III and IV on sodium channels in crayfish giant axons
3. Augmentation of recovery from inactivation by site-3 Na channel toxins: A single-channel and whole-cell study of persistent currents
4. Anemone toxin (ATX II)-induced increase in persistent sodium current: Effects on the firing properties of rat neocortical pyramidal neurones
5. The effects of the anemonia sulcata toxin (ATX II) on membrane currents of isolated mammalian myocytes
6. Effects of a toxin isolated from the sea anemone Bolocera tuediae on electrical properties of isolated rat skeletal muscle and cultured myotubes
7. Tetrodotoxin-insensitive sodium channels. Ion flux studies of neurotoxin action in a clonal rat muscle cell line
8. Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATX II
9. Super-sensitivity to tetrodotoxin and lignocaine of sea anemone toxin II-treated sodium channel in guinea-pig ventricular muscle
10. Effects of the Anemonia sulcata toxin (ATX II) on intracellular sodium and contractility in rat and guinea-pig myocardium
11. Electro-mechanical effects of anthopleurin-A (AP-A) on rabbit ventricular muscle: Influence of driving frequency, calcium antagonists, tetrodotoxin, lidocaine and ryanodine
12. The influence of the rate of electrical stimulation on the effects of the anemonia sulcata toxin ATX II in guinea pig papillary muscle
13. Blocking L-calcium current by 1-tetrahydropalmatine in single ventricular myocytes of guinea pig