Molecular mechanism of the metallothionein gene expression mediated by metal-responsive transcription factor 1

Journal of Health Science

Volumn 47, Issue 6, 2001, Pages 513-519

  Otsuka, F ^a  

^a TEIKYO UNIVERSITY   (Japan)

Author keywords

Heavy metal; Metal responsive element; Metallothionein; MTF 1; Transcription

Indexed keywords

CADMIUM; COMPLEMENTARY DNA; COPPER; DNA; HEAVY METAL; MERCURY; METAL RESPONSIVE TRANSCRIPTION FACTOR 1; METALLOTHIONEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC; ZINC FINGER PROTEIN;

ANIMAL CELL; BINDING SITE; DNA BINDING; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HEAVY METAL POISONING; HELA CELL; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; METAL RESPONSIVE ELEMENT; MOUSE; NONHUMAN; REVIEW; YEAST CELL;

ANIMALIA;

EID: 0035205337     PISSN: 13449702     EISSN: None     Source Type: Journal    
DOI: 10.1248/jhs.47.513     Document Type: Review

References (46)

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13. Characterization of the transcription factor MTF-1 from the Japanese pufferfish (Fugu rubripes) reveals evolutionary conservation of heavy metal stress response
14. Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein
15. Zinc-specific activation of a HeLa cell nuclear protein which interacts with a metal responsive element of the human metallothionein-IIA gene
16. Nuclear proteins binding to the human metallothionein-IIA gene upstream sequences
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22. Transcriptional activity and regulatory protein binding of metal-responsive elements of the human metallothionein-IIA gene
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24. Negative regulatory role of Sp1 in metal responsive element-mediated transcriptional activation
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26. Roles of zinc fingers and other regions of the transcription factor human MTF-1 in zinc-regulated DNA binding
27. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression
28. Regulation of metallothionein gene expression by oxidative stress and metal ions
29. Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements
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35. MRE-Binding transcription factor-1: Weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex
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37. Analysis of the heavy metal-responsive transcription factor MTF-1 from human and mouse
38. Zinc and cadmium can promote rapid nuclear translocation of metal response element-binding transcription factor-1
39. Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals
40. Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1
41. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium
42. Target gene search for the metal-responsive transcription factor MTF-1
43. The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene
44. Placenta growth factor gene expression is induced by hypoxia in fibroblasts: A central role for metal transcription factor-1