Local UV-induced DNA damage in cell nuclei results in local transcription inhibition

EMBO Reports

Volumn 2, Issue 11, 2001, Pages 1013-1017

  Moné, Martijn J ^a   Volker, Marcel ^b   Nikaido, Osamu ^c   Mullenders, Leon H F ^b   Van Zeeland, Albert A ^b   Verschure, Pernette J ^a   Manders, Erik M M ^a   Van Driel, Roel ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NUCLEOTIDE; TRANSCRIPTION FACTOR;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DEPLETION; DNA DAMAGE; DNA TRANSCRIPTION; EXCISION REPAIR; GENE REPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA SYNTHESIS; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION;

CELL NUCLEUS; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; FIBROBLASTS; HUMANS; MICROSCOPY, FLUORESCENCE; PLASMIDS; TIME FACTORS; TRANSCRIPTION FACTOR TFIIH; TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS, TFII; TRANSCRIPTION, GENETIC; ULTRAVIOLET RAYS;

EID: 0035204187     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve224     Document Type: Article

References (21)

1. UV damage causes uncontrolled DNA breakage in cells from patients with combined features of XP-D and Cockayne syndrome
2. The organization of replication and transcription
3. Molecular mechanism of nucleotide excision repair
4. The bases for Cockayne syndrome
5. TFIIH: A key component in multiple DNA transactions
6. Action of DNA repair endonuclease ERCC1/XPF in living cells
7. Visualization of focal sites of transcription within human nuclei
8. Failure of RNA synthesis to recover after UV irradiation: An early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum
9. Simultaneous establishment of monoclonal antibodies specific for either cyclobutane pyrimidine dimer or (6-4)photoproduct from the same mouse immunized with ultraviolet-irradiated DNA
10. Transcription response and nucleotide excision repair
11. TFIIH-mediated nucleotide excision repair and initiation of mRNA transcription in an optimized cell-free DNA repair and RNA transcription assay
12. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair
13. Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts
14. Cells from XP-D and XP-D-CS patients exhibit equally inefficient repair of UV-induced damage in transcribed genes but different capacity to recover UV-inhibited transcription
15. The sensitivity of Cockayne's syndrome cells to DNA-damaging agents is not due to defective transcription-coupled repair of active genes
16. The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA
17. Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP
18. Sequential assembly of the nucleotide excision repair factors in vivo
19. Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase-II in domains scattered throughout the nucleus
20. Yeast RNA polymerase II transcription in vitro is inhibited in the presence of nucleotide excision repair: Complementation of inhibition by holo-TFIIH and requirement for RAD26