Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes

Journal of Rheumatology

Volumn 28, Issue 12, 2001, Pages 2692-2699

  Maneiro, E ^a   Lopez Armada M J ^a   Fernandez Sueiro J L ^a   Lema, B ^a   Galdo, F ^a   Blanco, F J ^a  

^a HOSPITAL JUAN CANALEJO   (Spain)

Author keywords

Aceclofenac; Human Chondrocytes; Interleukin 1 receptor antagonist; Nitric oxide; Osteoarthritis; Prostaglandin E2

Indexed keywords

ACECLOFENAC; ACETYLSALICYLIC ACID; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTAGLANDIN E2; SOMATOMEDIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROSTAGLANDIN SYNTHESIS INHIBITION;

AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; CULTURE MEDIA, CONDITIONED; DICLOFENAC; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; LIPOPOLYSACCHARIDES; MIDDLE AGED; NITRIC OXIDE; OSTEOARTHRITIS, KNEE; PIROXICAM; SIALOGLYCOPROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035203728     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. The role of interleukin-1 in disease
2. Cytokine regulation of chondrocyte function
3. Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist
4. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
5. Lipopolysaccharide induces human interleukin-1 receptor antagonist and interleukin-1 production in the same cell
6. 2 and IL-1 Ra by human articular chondrocytes cultured in the presence of IL-1
7. IL-I Ra protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium
8. The synthesis of IL-1 receptor antagonist (IL-1 Ra) by synovial fibroblast is markedly increased by the cytokines TNF alpha and IL-1
9. Interleukin-1 receptor antagonist
10. Interleukin-1 receptor antagonist (IL-1 ra) as a probe and as a treatment for IL-1 mediated disease
11. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis
12. Evidence for the involvement of interleukin-1 in human osteoarthritic cartilage degradation: Protective effect of NSAIDs
13. Effects of tenidap on canine experimental osteoarthritis. Morphologic and metalloproteases analysis
14. In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha human osteoarthritic synovium and chondrocytes
15. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy
16. Modes of action of aspirin-like drugs
17. 2 production following its intracellular conversion into cyclooxygenase inhibitors
18. Synovial inflammatory factors in human osteoarthritis and their relevance in disease treatment with the NSAIDs aceclofenac and diclofenac
19. NSAID stimulation of human cartilage matrix synthesis. A study of the mechanism of action of aceclofenac
20. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes
21. Aceclofenac: Is the antiinflammatory effect really due to cyclooxygenase inhibition?
22. The type II decoy receptor: A novel regulatory pathway for interleukin 1
23. Reversal of autocrine and paracrine effects of interleukin 1 in human arthritis by type II IL-1 decoy receptor
24. Elevated levels of soluble interleukin-1 receptor type II and interleukin-1 receptor antagonist in patients with chronic arthritis: Correlations with markers of inflammation and joint destruction
25. The interleukin-1 receptor in normal and OA human articular chondrocytes: Identification as the type I receptor and analysis of binding kinetics and biologic function
26. The increased synthesis of inducible nitric oxide inhibits IL-1 ra synthesis by human articular chondrocytes: Possible role in osteoarthritic cartilage degradation
27. Modulation of human chondrocyte metabolism by recombinant human interferon
28. Binding of IL-1 alpha, IL-1 beta and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids
29. Down regulation of interleukin 1 beta production in human osteoarthritic synovial tissue and cartilage cultures by aminoguanidine
30. Increased IL-1 receptor antagonist production and decreased IL-1 beta/IL-1ra ratio in mononuclear cells from rheumatoid arthritis patients
31. Effects of nonsteroidal antiinflammatory drugs on interleukin-1 receptor antagonist production in cultured human peripheral blood mononuclear cells
32. Synthesis of metalloproteases and IL-6 in human osteoarthritic synovial membrane is an IL-1 mediated process
33. Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis
34. 2
35. Effects of nitric oxide on chondrocyte migration, adhesion and cytoskeletal assembly
36. Nitric oxide activates metalloproteases enzymes in articular cartilage
37. Chondrocyte apoptosis induced by nitric oxide
38. Regulation of nitric oxide production by salicylates and tenidap in human OA-affected cartilage, rat chondrosarcomas and bovine chondrocytes
39. Nitric oxide enhances cyclooxygenase activity in articular cartilage
40. Superinduction of cyclooxygenase-2 in human osteoarthritis-affected cartilage: Influence of nitric oxide