Enzyme specificity and tissue distribution of zenarestat, an aldose reductase inhibitor, and its relevance in the use of zenarestat as a therapeutic agent against diabetic neuropathy

Drug Development Research

Volumn 54, Issue 1, 2001, Pages 27-34

  Takakura, Shoji ^a   Minoura, Hideaki ^a   Shimoshige, Yukinori ^a   Minoura, Kyoko ^a   Kawamura, Ikuo ^a   Fujiwara, Tomoichi ^a   Saitoh, Takashi ^a   Shimojo, Fumio ^a   Seki, Jiro ^a   Goto, Toshio ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Aldose reductase; Diabetic neuropathies; Nervous system

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; GLUTATHIONE REDUCTASE; NITRIC OXIDE SYNTHASE; SORBITOL; ZENARESTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DRUG USE; ENZYME INHIBITION; ENZYME SPECIFICITY; KIDNEY CORTEX; LENS; MALE; NONHUMAN; RAT; RETINA; SCIATIC NERVE; SPINAL CORD; SPINAL GANGLION; TISSUE DISTRIBUTION;

EID: 0035195531     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.1201     Document Type: Article

References (6)

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