Molecular characterization of genomic AML1-ETO fusions in childhood leukemia

Leukemia

Volumn 15, Issue 12, 2001, Pages 1906-1913

  Xiao, Z ^a   Greaves, M F ^a   Buffler, P ^b   Smith, M T ^b   Segal, M R ^c   Dicks, B M ^d   Wiencke, J K ^d   Wiemels, J L ^d  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute myeloid leukemia; AML1; Cluster; ETO; Translocation

Indexed keywords

HYBRID PROTEIN; NUCLEOTIDE; RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL LINE; CHILDHOOD LEUKEMIA; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION 21; CHROMOSOME TRANSLOCATION 8; CONTROLLED STUDY; EXON; GENE CLUSTER; GENE DELETION; GENE DUPLICATION; GENE EXPRESSION; GENE FUSION; GENE INSERTION; GENE SEQUENCE; GENE STRUCTURE; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; HYPOTHESIS; INTRON; PRIORITY JOURNAL; SAMPLE; SEQUENCE HOMOLOGY; STATISTICAL ANALYSIS;

EID: 0035195004     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402318     Document Type: Article

References (62)

1. Disruption of the multiple tumor suppressor gene MTS1/p16(INK4a)/CDKN2 by illegitimate V(D)J recombinase activity in T-cell acute lymphoblastic leukemias
2. Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: Novel insights into the mechanism of t(14;18) translocation
3. The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V-D-J joining
4. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
5. Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity
6. Different genetic pathways in leukemogenesis for patients presenting with therapy-related myelodysplasia and therapy-related acute myeloid leukemia
7. The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion
8. Therapy-related acute myeloid leukemia with t(8;21), inv(16), and t(8;16): A report on 25 cases and review of the literature
9. CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: Association with prior therapy
10. Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations
11. Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites
12. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: Correlation with scaffold attachment regions and topoisomerase sites
13. Rapid isolation of chromosomal breakpoints from patients with t(4;11) acute lymphoblastic leukemia: Implications for basic and clinical research
14. Microclustering of TEL-AML1 breakpoints in childhood acute lymphoblastic leukemia
15. Genomic acute myeloid leukemia-associated inv(16)(p13q22) breakpoints are tightly clustered
16. Analysis of the joining sequences of the t(15;17) translocation in human acute promyelocytic leukemia: Sequence non-specific recombination between the PML and RARA genes within identical short stretches
17. Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpoints
18. Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): A report from the Children's Cancer Group
19. Infant leukemia, topoisomerase II inhibitors, and the MLL gene
20. Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion
21. ETV6-AML1 translocation breakpoints cluster near a purine/pyrimidine repeat region in the ETV6 gene
22. Structure and possible mechanisms of TEL-AML1 gene fusions in childhood acute lymphoblastic leukemia
23. Molecular analysis of chromosomal breakpoints in three examples of chromosomal translocation involving the TEL gene
24. Characterization of t(12;21) breakpoint junctions in acute lymphoblastic leukemia
25. Balanced translocations involving chromosome bands 11q23 and 21q22 in therapy-related leukemia
26. Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II
27. Increased risk of myelodysplasia and leukaemia after etoposide, cisplatin, and bleomycin for germ-cell tumours
28. Acute monocytic or myelomonocytic leukemia with balanced chromosome translocations to band 11q23 after therapy with 4-epi-doxorubicin and cisplatin or cyclophosphamide for breast cancer
29. Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation
30. Morphologic, immunologic and cytogenetic studies in acute myeloid leukemia following occupational exposure to pesticides and organic solvents
31. Correlation of occupation and karyotype in adults with acute nonlymphocytic leukemia
32. Specific chromosome changes and non-occupational exposure to potentially carcinogenic agents in acute leukemia in China
33. Chromosome pattern, occupation, and clinical features in patients with acute nonlymphocytic leukemia
34. Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations
35. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family
36. The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: Biology and clinical significance
37. t(8;21) breakpoints are clustered between alternatively spliced exons of MTG8
38. Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2
39. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
40. Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation
41. Establishment of a myeloid leukaemic cell line (SKNO-1) from a patient with t(8;21) who acquired monosomy 17 during disease progression
42. Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation
43. Large deviation approximations to the distribution of scan statistics
44. Approximating the distribution of the scan statistic using moments of the number of clumps
45. Clustering of translocation breakpoints
46. Using kernel density estimates to investigate multi-modality
47. Is AML1/ETO gene expression a good prognostic factor in pediatric acute myeloblastic leukemia?
48. Prognostic importance of cytogenetic subgroups in de novo pediatric acute nonlymphocytic leukemia
49. Clinical and prognostic significance of chromosomal abnormalities in childhood acute myeloid leukemia de novo
50. Analysis of genes under the downstream control of the t(8;21) fusion protein AML1-MTG8: Overexpression of the TIS11b (ERF-1, cMG1) gene induces myeloid cell proliferation in response to G-CSF
51. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation
52. Molecular diversity in AML1/ETO fusion transcripts in patients with t(8;21) positive acute myeloid leukaemia
53. Expression of diverse AML1/MTG8 transcripts is a consistent feature in acute myeloid leukemia with t(8;21) irrespective of disease phase
54. Acute myeloid leukemia M2b (subacute myelogenous leukemia) in China
55. A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells
56. Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): The DNA damage-repair model of translocation
57. Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL
58. Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia
59. Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero
60. Prenatal origin of acute lymphoblastic leukaemia in children
61. Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene
62. Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus