AIDS cardiomyopathy: Physiological, molecular, and biochemical studies in the transgenic mouse

Annals of the New York Academy of Sciences

Volumn 946, Issue , 2001, Pages 46-56

  Lewis, William ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AIDS; Cardiomyopathy; HAART; Transgenic mice

Indexed keywords

ANTIRETROVIRUS AGENT; ATRIAL NATRIURETIC FACTOR; GENE PRODUCT; LAMIVUDINE; MYOSIN HEAVY CHAIN; SODIUM CALCIUM EXCHANGE PROTEIN; STAVUDINE; ZIDOVUDINE;

ACIDOSIS; ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANION GAP; CARDIOMYOPATHY; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; GENETIC RECOMBINATION; HUMAN IMMUNODEFICIENCY VIRUS 1; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROMOTER REGION; SPECIES DIFFERENCE; TRANSGENIC MOUSE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS;

EID: 0035194357     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03902.x     Document Type: Conference Paper

References (47)

1. Cardiomyopathy in AIDS: A pathophysiological perspective
2. Guide to major clinical trials of antiretroviral therapy administered to patients infected with human immunodeficiency virus
3. Antiretroviral therapy for HIV infection in 1996. Recommendations of an international panel
4. The early region of human papovavirus JC induces dysmyelination in transgenic mice
5. A transgenic mouse model for human neurofibromatosis
6. Virus antigens: Localization of epitopes involved in hemagglutination and neutralization by using monoclonal antibodies
7. HBx gene of hepatitis B virus induces liver cancer in transgenic mice
8. Transgenic models of human immunodeficiency virus type-1
9. The pathogenic role of human immunodeficiency virus accessory genes in transgenic mice
10. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
11. AIDS retrovirus (ARV-2) clone replicates in transfected human and animal fibroblasts
12. Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice
13. Human chromosome 12 is required for optimal interactions between Tat and TAR of human immunodeficiency virus type 1 in rodent cells
14. The induction of cataracts by HIV-1 in transgenic mice
15. HIV-associated nephropathy in transgenic mice expressing HIV-1 genes
16. Cutaneous disorders and viral gene expression in HIV-1 transgenic mice
17. Transcription of HIV-1 genes in transgenic mice is associated with myopathy and myositis
18. Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes
19. Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome
20. Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts
21. Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria
22. Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine
23. Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU triphosphate
24. Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts
25. Depletion of mitochondrial DNA, destruction of mitochondria, and accumulation of lipid droplets result from fialuridine treatment in woodchucks (Marmota monax)
26. Zidovudine causes early increases in mitochondrial ribonucleic acid abundance and induces ultrastructural changes in cultured mouse muscle cells
27. Mitochondrial toxicity of antiviral drugs
28. Mitochondrial toxicity - New adverse drug effects
29. Differences in Anion gap with different nucleoside RTI combinations
30. Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart
31. Transgenic remodeling of the contractile apparatus in the mammalian heart
32. The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice
33. HIV-1 Tat construct targeted to adult cardiac ventricular myocytes alters heart structure and function
34. Liver cancer in transgenic mice carrying the human immunodeficiency virus tat gene
35. Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes
36. HIV-1 tat acts as a growth factor and induces angiogenic activity in BK virus/tat transgenic mice
37. Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice
38. Expression of the human immunodeficiency virus-Tat gene in lymphoid tissues of transgenic mice is associated with B-cell lymphoma
39. The human immunodeficiency virus type 1 Tat protein potentiates zidovudine-induced cellular toxicity in transgenic mice
40. Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice
41. Susceptibility of HIV-1-TAT transfected cells to undergo apoptosis
42. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress
43. Persistent infection of normal mice with human immunodeficiency virus
44. Of mice, oncogenes, and Rifkin [news]
45. Cell-mediated immune response toward viral envelope and core antigens in gibbon apes (Hylobates lar) chronically infected with human immunodeficiency virus-1
46. Human immunodeficiency virus pseudotypes with expanded cellular and species tropism
47. Genetics of retroviruses