Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs

Drug Metabolism and Disposition

Volumn 29, Issue 12, 2001, Pages 1599-1607

  Obach, R S ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE DERIVATIVE; BENZYL ALCOHOL; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEUTERIUM; EZLOPITANT; ISOTOPE;

ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; DRUG METABOLISM; DRUG STRUCTURE; HYDROGENATION; MOLECULAR INTERACTION; PRIORITY JOURNAL; REACTION ANALYSIS; VELOCITY;

BENZYLAMINES; BICYCLO COMPOUNDS, HETEROCYCLIC; CATALYSIS; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DEUTERIUM; ISOTOPE LABELING; KINETICS; MIXED FUNCTION OXYGENASES; RECEPTORS, NEUROKININ-1; RECOMBINANT PROTEINS;

EID: 0035193411     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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