Conjugation reactions catalyzed by bifunctional proteins related to β-oxidation in bile acid biosynthesis

Steroids

Volumn 66, Issue 2, 2001, Pages 107-114

  Kurosawa, Takao ^a   Sato, Masahiro ^a   Nakano, Hiroyuki ^a   Fujiwara, Masato ^a   Murai, Tsuyoshi ^a   Yoshimura, Teruki ^a   Hashimoto, Takashi ^b  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bile acid; Conjugated reaction; D bifunctional protein; HPLC analysis; L bifunctional protein; Steroids

Indexed keywords

BILE ACID; HYDROLYASE; OXIDOREDUCTASE; PROTEIN;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CONJUGATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDRATION;

17-HYDROXYSTEROID DEHYDROGENASES; 3-HYDROXYACYL COA DEHYDROGENASES; BILE ACIDS AND SALTS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENOYL-COA HYDRATASE; HYDRO-LYASES; MULTIENZYME COMPLEXES; OXIDATION-REDUCTION;

EID: 0035192923     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(00)00217-8     Document Type: Article

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3. Formation of chenodeoxycholic acid from 3α,7α-dihydroxy-5β-cholestan-26-oic acid by rat liver peroxisomes
4. Bile acid biosynthesis
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6. Identification of 3α,7α,12α-trihydroxy-5β-cholest-24-enoic acid as an intermediate in the peroxisomal conversion of 3α,7α,12α-trihydroxy-5β-cholestanoic acid to cholic acid
7. Identification of (24E)-3α,7α-dihydroxy-5β-cholest-24-en-26-oic acid and (24R,25S)-3α,7α,24-trihydroxy-5β-cholestan-26-oic acid as intermediates in the conversion of 3α,7α-dihydroxy-5β-cholestan-26-oic acid to chenodeoxycholic acid in rat liver homogenates
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21. Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C27-bile acids di- and trihydroxycoprostanoic acids are metabolized by separate multifunctional proteins
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