Does the antitumor cyclopropylpyrroloindole antibiotic CC-1065 cross-link DNA in tumor cells?

Biochemical Pharmacology

Volumn 61, Issue 1, 2001, Pages 67-72

  Skladanowski, Andrzej ^a   Koba, Marcin ^a   Konopa, Jerzy ^a  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

CC 1065; Cytotoxicity; Interstrand DNA cross links; Metabolic activation

Indexed keywords

ADOZELESIN; ANTIBIOTIC AGENT; BIZELESIN; DNA; INDOLE DERIVATIVE; RACHELMYCIN; U 56314;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DRUG MECHANISM; DRUG POTENCY; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL;

ANTIBIOTICS, ANTINEOPLASTIC; CELL DIVISION; CROSS-LINKING REAGENTS; CYCLOHEXANECARBOXYLIC ACIDS; CYCLOHEXENES; DNA; DNA, NEOPLASM; HELA CELLS; HUMANS; INDOLES; LEUCOMYCINS; UREA;

EID: 0035191970     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00528-1     Document Type: Article

References (26)

1. CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism
2. Covalent binding of antitumor antibiotic in the minor groove of DNA. Mechanism of action of CC-1065 and the pyrrolo(1,4)benzoadepines
3. CC-1065
4. Structure and activity relationship of several novel CC-1065 analogs
5. DNA interstrand cross-linking, DNA sequence specificity, and induced conformational changes produced by a dimeric analog of (+)-CC-1065
6. Nucleotide preference for DNA interstrand cross-linking induced by the cyclopropylpyrroloindole analogue U-77,779
7. Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity
8. CC-1065 bonding to intracellular and purified SV40 DNA: Site specificity and functional effects
9. Induction of heat-labile sites in DNA of mammalian cells by the antitumor alkylating drug CC-1065
10. Characterization of a duocarmycin-DNA adduct-recognizing protein in cancer cells
11. DNA bifunctional intercalators. 1. Synthesis and conformational properties of an ethidium homodimer and an acridine heterodimer
12. Characterization of PicoGreen reagent and development of a fluorescence-based solution assay for double-stranded DNA quantitation
13. Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors
14. Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells
15. Interstrand DNA crosslinking induced by anthracyclines in tumour cells
16. Ethidium dimer: A new reagent for the fluorimetric determination of nucleic acids
17. Myeloperoxidase: A myeloid cell nuclear antigen with DNA-binding properties
18. Localization of prostaglandin endoperoxide synthase-1 to the endoplasmic reticulum and nuclear envelope is independent of its C-terminal tetrapeptide-PTEL
19. Induction of AT-specific DNA-interstrand crosslinks by bizelesin in genomic and simian virus 40 DNA
20. Detection of DNA crosslinks in tumor cells with ethidium bromide fluorescence assay
21. DNA interstrand cross-links induced by the cyclopropylpyrroloindole antitumor agent bizelesin are reversible upon exposure to alkali
22. DNA damage and differential cytotoxicity produced in human carcinoma cells by CC-1065 analogues, U-73,975 and U-77,779
23. Cytochrome P-450-mediated O-demethylation: A route in the metabolic activation of etoposide (VP-16-213)
24. Chemical modifications of biopolymers by quinones and quinone methides
25. Structure, chemistry, and biosynthesis of melanins
26. Molecular and cellular pharmacology of novel photoactive psoralen and coumarin conjugate of pyrrole- and imidazole-containing analogues of neotropsin