The activity of vancomycin against heterogeneous vancomycin-intermediate methicillin-resistant Staphylococcus aureus explored using an in vitro pharmacokinetic model

Journal of Antimicrobial Chemotherapy

Volumn 48, Issue 5, 2001, Pages 727-730

  Turner, Jonathan ^a,b   Howe, Robin A ^a,b   Wootton, Mandy ^a,b   Bowker, Karen E ^a,b   Holt, H Alan ^a,b   Salisbury, Vyvyan ^a,c   Bennett, Peter M ^a,d   Walsh, Timothy R ^a,d   MacGowan, Alasdair P ^a,b  

^a Bristol Centre for Antimicrobial Research and Evaluation   (United Kingdom)

^b SOUTHMEAD HOSPITAL   (United Kingdom)

^c UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

^d SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METICILLIN; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CELL POPULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DILUTION; DRUG EXPOSURE; GROWTH REGULATION; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MODEL; NONHUMAN; PHARMACOKINETICS; PHENOTYPE; TIME; TREATMENT FAILURE;

EID: 0035188998     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/48.5.727     Document Type: Article

References (10)

1. Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
2. Activities of LY 333328 and vancomycin administered alone or in combination with gentamicin against three strains of vancomycin-intermediate Staphylococcus aureus in an in vitro pharmacodynamic infection model
3. In vitro activities of daptomycin, arbekacin, vancomycin and gentamicin alone and/or in combination against glycopeptide intermediate-resistant Staphylococcus aureus in an infection model
4. Vancomycin resistant Stayphylococcus aureus
5. A guide to sensitivity testing
6. Efficacies of different vancomycin dosing regimens against Staphylococcus aureus determined with a dynamic in vitro model
7. Activities of vancomycin and teicoplanin against penicillin-resistant pneumococci in vitro and in vivo and correlations to pharmacokinetic parameters in the mouse peritonitis model
8. Pharmacokinetic-pharmacodynamic indices for vancomycin treatment of susceptible and intermediate Staphylococcus aureus in the neutropenic mouse thigh model
9. Characterisation of passage-selected vancomycin-resistant Staphylococcus aureus strains of diverse parental background