Protein kinase A of Leishmania amazonensis as a potential target for methoxy-amidine

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 11, 2001, Pages 920-923

  Genestra, M ^a   Echevarria, A ^a   Cysne Finkelstei, L ^a   Leon, L L ^a  

^a AV Brasil 4365 ^*  (Brazil)

Author keywords

Amidines; CAS 100 33 4; Leishmania amazonesis, amastigotes, promastigotes; Methoxy amidine; Pentamidine; Protein kinase A, cAMP dependent

Indexed keywords

AMIDINE; ANTIPROTOZOAL AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; METHOXYAMIDINE; PENTAMIDINE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; LEISHMANIA; LEISHMANIASIS; NONHUMAN;

EID: 0035186892     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300138     Document Type: Article

References (26)

1. Antigenic differences of Leishmania amazonensis isolates causing diffuse cutaneous leishmaniasis
2. Identification of serine/threonine protein kinases secreted by Trichinella spiralis infective larvae
3. 3H-thymidine incorporation in human fibroblasts
4. Early signals in the mitogenic response
5. Localization of protein kinases by anchoring proteins: A theme in signal transduction
6. Effect of protein kinase inhibitors on the growth, morphology and infectivity of Leishmania promastigotes
7. Trypanosoma cruzi: Adrenergic modulation of cyclic AMP role in proliferation and differentiation of amastigotes in vitro
8. Distinct patterns of tyrosine phosphorylation during the life cycle of Trypanosoma brucei
9. Possible role of cAMP in the differentiation of Trypanosoma cruzi
10. Intracellular signaling transduction in the differentiation of T. cruzi: Role of cAMP
11. Inhibitory action of elevated levels of adenosine-3′-5′-cyclic monophosphate on phagocytosis: Effects on macrophage-Trypanosoma cruzi interaction
12. Characterization and classification of leishmanial parasites from humans, wild mammals and sandflies in Amazon Region, Brazil
13. Leishmania amazonensis: Long-term cultivation of axenic amastigotes is associated to metacyclogenesis of promastigotes
14. Effect of amidine derivatives on Leishmania amazonensis axenic amastigotes
15. Synthesis, characterization and anti-HIV activity of some 2-p-X-phenyl1,3-N,N'-diphenylbenzamidines
16. Cyclic AMP-dependent protein kinase activity in Trypanosoma cruzi
17. Protein kinase A inhibitors enhance radiation-induced apoptosis
18. Phosphorylative activity of a cyclic adenosine monophosphate-dependent protein kinase in L. amazonensis
19. Protein kinase activities in Leishmania aethiopica: Control by growth, transformation and inhibitors
20. Phosphorylation and antileishmanial activity of formycin B
21. Growth of Trypanosoma cruzi epimastigotes controlled by shifts in cyclic AMP mediated by adrenergic ligands
22. Signal transduction in Trypanosoma cruzi: Opposite effects of adenylcyclase and phospholipase C systems in growth control
23. cAMP-dependent protein kinase: Framework for a diverse family of regulatory enzymes