The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats

Clinical Science

Volumn 100, Issue 1, 2001, Pages 55-60

  Naderali, E K ^a   Smith, S L ^a   Doyle, P J ^a   Williams, G ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Calcium channels; Endothelium; NO synthesis inhibitor; Resistance arteries; Resveratrol

Indexed keywords

ACETYLCHOLINE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NORADRENALIN; RESVERATROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CONSTRICTION; ARTERY RESISTANCE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; LEAN BODY WEIGHT; MALE; MESENTERIC ARTERY; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

ACETYLCHOLINE; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENDOTHELIUM, VASCULAR; INDOMETHACIN; MALE; MESENTERIC ARTERIES; NG-NITROARGININE METHYL ESTER; NOREPINEPHRINE; OBESITY; RATS; RATS, WISTAR; STILBENES; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 0035179955     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20000123     Document Type: Article

References (38)

1. Antimutagenic effects of resveratrol against Trp-P-1
2. Isolation, synthesis, and antiplatelet aggregation activity of resveratrol 3-O-b-D-Glucopyranoside and related compounds
3. Content of resveratrol, piceid and their isomers in commercially available wines made from grapes cultivated in Japan
4. Resveratrol content of some wines obtained from dried Valpolicella grapes: Recioto and Amarone
5. Interaction of transresveratrol with plasma lipoproteins
6. Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations
7. Wines and grape juices as modulators of platelet aggregation in healthy human subjects
8. Resveratrol activity on guinea-pig isolated trachea from normal and albumin-sensitized animals
9. Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationship
10. Vasorelaxant activity of resveratrol and quercetin in isolated rat aorta
11. Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta
12. The red wine phenolic trans-reseveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease
13. Effects of red wine on endothelium-dependent relaxation in rabbits
14. Reseveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs
15. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
16. Role of endothelial dysfunction in coronary artery disease
17. Endothelial dysfunction in human disease
18. Endothelial dysfunction: From physiology to therapy
19. Nitric oxide synthase: Role in the genesis of vascular disease
20. Endothelial dysfunction: Cause of the insulin resistance syndrome
21. Primary endothelial dysfunction: Atherosclerosis
22. Impaired vasodilatation of forearm resistance vessels in hypercholesterolemic humans
23. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus
24. Obesity/insulin resistance is associated with endothelial dysfunction: Implications for the Syndrome of insulin resistance
25. Impaired endothelium-dependent and independent dilatation of forearm arteries in men with diet-treated noninsulin-dependent diabetes: Role of dyslipidaemia
26. Evidence of impaired endothelial function in dietary-induced obese rats
27. Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA, in diet-induced obesity in rats
28. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats
29. Differential vasoactive effects of the insulin sensitizers rosiglitazone (BRL 49653) nd troglitazone on human small arteries in vitro
30. Comparable vasorelaxant effects of 17a- and 17b-oestradiol on rat mesenteric resistance arteries: An action independent of the oestrogen receptors
31. Endothelium-dependent vasorelaxation caused by various plant extracts
32. Endothelium-dependent and independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors
33. Role of phosphodiesterases III and IV in the modulation of vascular cyclic AMP content by the NO/cyclic GMP pathway
34. Inhibition of human platelet cyclic AMP phosphodiesterase and platelet aggregation by hemisynthetic flavonoid, amentoflavone hexaacetate
35. Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effects of prostacyclin
36. Relaxant effect of trans-resveratrol on isolated porcine coronary arteries
37. Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta
38. Extract of wine phenolic improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats