Tamoxifen inhibits endothelial cell proliferation and attenuates VEGF-mediated angiogenesis and migration in vivo

European Journal of Surgical Oncology

Volumn 27, Issue 8, 2001, Pages 714-718

  McNamara, D A ^a   Harmey, J ^a   Wang, J H ^a   Kay, E ^a   Walsh, T N ^a   Bouchier Hayes, D J ^a  

^a BEAUMONT HOSPITAL   (Ireland)

Author keywords

Angiogenesis; Tamoxifen; Vascular endothelial growth factor (VEGF)

Indexed keywords

BROXURIDINE; CYTOKINE; DRUG VEHICLE; MATRIGEL; TAMOXIFEN; VASCULOTROPIN;

ADJUVANT THERAPY; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; BLOOD LEVEL; CANCER PATIENT; CELL CULTURE; CELL LABELING; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MALE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SKIN BLOOD VESSEL; SURGICAL INJURY; TUMOR GROWTH;

EID: 0035176772     PISSN: 07487983     EISSN: None     Source Type: Journal    
DOI: 10.1053/ejso.2001.1177     Document Type: Article

References (15)

1. Tamoxifen: Teaching an old drug new tricks?
2. Antioestrogens inhibit endothelial cell growth stimulated by angiogenic growth factors
3. Angiogenic factors
4. Insulin-like growth I factor gene expression in the uterus is stimulated by tamoxifen and inhibited by the pure antioestrogen ICI 182780
5. Induction of transforming growth factor βI in human breast cancer in vivo following tamoxifen treatment
6. Antioestrogenic compounds inhibit estrogen-induced expressions of basic fibroblast growth factor and its mRNA in well-differentiated endometrial cancer cells
7. Vascular endothelial growth factor in breast cancer and novel mechanisms of tamoxifen
8. Ascites revisited: A novel role for tamoxifen
9. Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma
10. Angiogenesis in breast cancer
11. Estimating the reproducibility of microvessel density measurements by different methods in breast cancer
12. Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment
13. Metabolites, pharmacodynamics and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient
14. The effect of laparotomy and laparoscopy on the establishment of spontaneous tumour metastases
15. The role of endotoxin/LPS in surgically induced tumour growth in a murine model of metastatic disease