Identification of sequences in the human peptide transporter subunit TAP1 required for transporter associated with antigen processing (TAP) function

International Immunology

Volumn 13, Issue 1, 2001, Pages 31-41

  Ritz, Ulrike ^a   Momburg, Frank ^b   Pircher, Hans Peter ^c   Strand, Dennis ^a   Huber, Christoph ^a   Seliger, Barbara ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Antigen presentation; Antigen processing; MHC; Peptide transporter; T cell response

Indexed keywords

ABC TRANSPORTER; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MUTANT PROTEIN; PEPTIDE; PROTEIN SUBUNIT; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOLYSIS; CYTOSOL; CYTOTOXIC T LYMPHOCYTE; ENDOPLASMIC RETICULUM; HUMAN; INTRACELLULAR TRANSPORT; MOLECULAR MODEL; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 0035176309     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.1.31     Document Type: Article

References (42)

1. Proteolysis, proteasomes and antigen presentation
2. Selectivity and ATP-dependent translocation of peptides by the MHC-encoded transporter
3. Peptide size selection by the major histocompatibility complex-encoded peptide transporter
4. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP
5. Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules
6. Evidence for successive peptide binding and quality control stages during MHC class I assembly
7. Retention of empty MHC class I molecules by tapasin is essential to reconstitute antigen presentation in invertebrate cells
8. 2-microglobulin complexes associate with TAP transporters before peptide binding
9. Interaction of MHC class I molecules with the transporter associated with antigen processing
10. Nucleotide binding by TAP mediates association with peptide and release of assembled MHC class I molecules
11. A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway
12. Sequence encoded in the class II region of the MHC related to the ABC superfamily of transporters
13. Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region
14. A sequential model for peptide binding and transport by the transporters associated with antigen processing
15. Evidence that the transporter associated with antigen processing translocate a major histocompatibility complex class I binding peptide into the endoplasmic reticulum in an ATP-dependent manner
16. Nucleotide binding to the hydrophobic C-terminal domain of the transporter associated with antigen processing (TAP)
17. Restoration of antigenic presentation to the mutant cell line RMA-S by an MHC-linked transporter
18. Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer
19. + T cells
20. A viral inhibitor of peptide transporters for antigen presentation
21. Membrane topology of the ATP-binding cassette transporter associated with antigen presentation (TAP1) expressed in Escherichia coli
22. Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site
23. Head-head/tail-tail relative orientation of the pore-forming domains of the heterodimeric ABC transporter TAP
24. Membrane topology and dimerization of the two subunits of the transporter associated with antigen processing reveal a three-domain structure
25. The major substrates for TAP in vivo are derived from newly synthesized proteins
26. Residues in TAP2 peptide transporters controlling substrate specificity
27. A point mutation in the human transporter associated with antigen processing (TAP2) alters peptide transport specificity
28. Induction of immunogenicity of a human renal-cell carcinoma cell line by TAP-gene transfer
29. Rapid and efficient site-specific mutagenesis without phenotypic selection
30. Functional expression and purification of the ABC transporter complex associated with antigen processing (TAP) in insect cells
31. Cell lines transfected with the TAP inhibitor ICP47 allow testing peptide binding to a variety of HLA class I molecules
32. Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling, and all three are regulated by H2D
33. Strictly transporter of antigen presentation (TAP)-dependent presentation of an immunodominant cytotoxic T lymphocyte epitope in the signal sequence of a virus protein
34. Studies of human MDR1-MDR2 chimeras demonstrate the functional exchange-ability of a major transmembrane segment of the multidrug transporter and phosphatidylcholine flippase
35. A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer
36. Homozygous human TAP transporter mutation in HLA class I deficiency
37. HLA class I deficiencies due to mutations in subunit 1 of the peptide transporter TAP1
38. Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome
39. Differential effect of transporter TAP2 gene introduction into RMA-S cells on viral antigen processing
40. An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S
41. TAP2 defective RMA-S cells present Sendai virus antigen to cytotoxic T lymphocytes
42. Recognition principle of the TAP transporters disclosed by combinatorial peptide libraries