Therapeutic angiogenesis in critical limb and myocardial ischemia

Journal of Interventional Cardiology

Volumn 14, Issue 5, 2001, Pages 511-528

  Vale, Peter R ^a   Isner, Jeffrey M ^a   Rosenfield, Kenneth ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST ELIZABETH'S MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; NITRATE; RECOMBINANT FIBROBLAST GROWTH FACTOR; RECOMBINANT TRANSCRIPTION FACTOR HIF 1ALPHA; RECOMBINANT VASCULOTROPIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANEMIA; ANGIOGENESIS; CARCINOGENICITY; CELL PROLIFERATION; CLAUDICATION; CLINICAL TRIAL; COLLATERAL CIRCULATION; CONFERENCE PAPER; DIGITAL SUBTRACTION ANGIOGRAPHY; DRUG ADMINISTRATION; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; EDEMA; ENDOTHELIUM CELL; EPICARDIUM; GENE THERAPY; GENE TRANSFER; HEART CATHETER; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HUMAN; HYPOTENSION; IMAGING SYSTEM; INTRACORONARY INFUSION; LIMB ISCHEMIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PERICARDIUM; PRIORITY JOURNAL; RESTENOSIS; SMOOTH MUSCLE FIBER; SUPERFICIAL FEMORAL ARTERY; THROMBOCYTOPENIA;

EID: 0035173338     PISSN: 08964327     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8183.2001.tb00367.x     Document Type: Conference Paper

References (144)

1. Tumor angiogenesis: Therapeutic implications
2. Differentiation of endothelium
3. In vitro differentiation of murine embryonic stem ceils: New approaches to old problems
4. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of hematopoietic stem cells and is encoded by variant RNAs
5. Vasculogenesis
6. Induction of vasculogenesis and hematopoiesis in vitro
7. Angiogenesis
8. Mechanisms of angiogenesis
9. Therapeutic angiogenesis: A single intra-arterial bolus of vascular endothelial growth factor augments collateral vessel formation in a rabbit ischemic hindlimb
10. 165 following intramuscular gene transfer promotes collateral vessel development in patients with CLI
11. Induction of neoangiogenesis in ischemic myocardium by human growth factors: First clinical results of a new treatment of coronary heart disease
12. 165 as sole therapy for myocardial ischemia
13. Angiogenesis gene therapy: Phase I assessment of direct intramyocardial administration of an adenovirus vector expression VEGF-121 cDNA to individuals with clinically significant severe coronary artery disease
14. Isolation of putative progenitor endothelial cells for angiogenesis
15. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
16. Bone marrow origin of endothelial progenitor ceils responsible for postnatal vasculogenesis in physiological and pathological neovascularization
17. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
18. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb
19. Mechanisms of angiogenesis
20. Migration and proliferation of endothelial ceils in preformed and newly formed blood vessels during tumor angiogenesis
21. DNA synthesis and mitoses in coronary collateral vessels of the dog
22. DNA synthesis in coronary collaterals after coronary artery occlusion in conscious dog
23. Coronary collateral development in swine after coronary artery occlusion
24. Time course of increased cellular proliferation in collateral arteries following administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency
25. VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts
26. Lower extremity edema associated with gene transfer of naked DNA vascular endothelial growth factor
27. Preclinical and clinical studies with recombinant human basic fibroblast growth factor
28. A double-blind, placebo-controlled, phase II study of basic fibroblast growth factor in the treatment of intermittent claudication
29. Increased expression of direct gene transfer into skeletal muscles observed after acute ischemic injury in rats
30. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue peffusion
31. Time course of recombinant protein secretion following liposome-mediated gene transfer in a rabbit arterial organ culture model
32. Use of the rabbit ear artery to serially assess foreign protein secretion after site-specific arterial gene transfer in vivo: Evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expression
33. Role of Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
34. Failure of blood-island formation and vasculogenesis in Flk-1 deficient mice
35. Molecular analysis of blood vessel formation and disease
36. Hypoxia-induced paracrine regulation of VEGF receptor expression
37. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
38. Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia
39. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
40. Vascular endothelial growth factor B, a novel growth factor for endothelial cells
41. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor
42. Vascular endothelial growth factor is a secreted angiogenic mitogen
43. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
44. Purification of glycoprotein vascular endothelial cell mitogen from a rat glioma cell line
45. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
46. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
47. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth
48. Reciprocal relationship between VEGF and NO in the regulation of endothelial integrity
49. Therapeutic angiogenesis: A single intra-arterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hindlimb model
50. 165
51. Angiogenesis in cancer, vascular, rheumatoid and other diseases
52. Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries
53. Recombinant rat stem cell factor synergizes with recombinant human granulocyte colony stimulating factor in vivo in mice to mobilize peripheral blood progenitor ceils that have enhanced repopulating potential
54. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia
55. Vascular endothelial growth factor165 gene transfer augments circulating endothelial progenitor cells in human subjects
56. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
57. 165 in patients with inoperable coronary disease
58. Mechanisms of angiogenesis and arteriogenesis
59. Arterial gene transfer of acidic fibroblast growth factor for therapeutic angiogenesis in vivo: Critical role of secretion signal in use of naked DNA
60. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart
61. Intracoronary gene transfer of fibroblast growth factor-4 increases regional contractile function and responsiveness to adrenergic stimulation in heart failure
62. Second European consensus document on chronic critical leg ischemia
63. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis
64. Arterial gene transfer using pure DNA applied directly to a hydrogel-coated angioplasty balloon
65. Site-specific gene expression in vivo by direct gene transfer into arterial wall
66. Gene therapy for cardiovascular disease
67. Arterial gene transfer for therapeutic angiogenesis in patients with peripheral artery disease
68. Failure of angiography to accurately depict the extent of coronary arterial narrowing in three fatal cases of percutaneous transluminal coronary angioplasty
69. Low efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit
70. Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF
71. Standards for evaluating and reporting the results of surgical and percutaneous therapy for peripheral arterial disease
72. 165 in patients with CLI
73. Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results
74. Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia: Dose-response effect of basic fibroblast growth factor
75. Basic fibroblast growth factor increases collateral blood flow in rats with femoral artery ligation
76. Basic FGF enhances the development of collateral circulation after acute arterial occlusion
77. Basic fibroblast growth factor in patients with intermittent claudication: Results of a phase I trial
78. Direct intramuscular injection of plasmid DNA encoding angiopoietin-1, but not angiopoietin-2, augments revascularization in the rabbit ischemic hindlimb
79. Angiogenesis induced by adenovirus-mediated gene transfer of a hypoxia-inducible factor-1a/VP16 hybrid in rabbit hindlimb ischemia
80. Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia
81. 125I-labeled basic fibroblast growth factor (bFGF) favor intramyocardial delivery
82. VEGF administration in chronic myocardial ischemia in pigs
83. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs
84. Intramyocardial but not intravenous vascular endothelial growth factor improves regional perfusion in hibernating porcine myocardium
85. Vascular endothelial growth factor in chronic myocardial ischemia
86. Direct myocardial transfection in two animal models: Evaluation of parameters affecting gene expression and percutaneous gene delivery
87. Catheter-based gene transfer of VEGF utilizing electromechanical LV mapping accomplishes therapeutic angiogenesis: Preclinical studies in swine
88. Intramyocardial gene therapy with naked DNA encoding vascular endothelial growth factor improves collateral flow to ischemic myocardium
89. Percutaneous electromechanical mapping demonstrates efficacy of pVGI.1 (VEGF2) in an animal model of chronic myocardial ischemia
90. Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart
91. Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121
92. Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: Effect on myocardial angiogenesis
93. Cather-based myocardial gene transfer utilizing nonfiuoroscopic electromechanical left ventricular mapping
94. Percutaneous endocardial gene therapy: Patterns of in vivo gene expression related to regional myocardial delivery
95. 121 offers equivalent gene delivery and protein expression compared to a surgical-based transepicardial injection approach
96. Basic fibroblast growth factor enhances myocardial collateral flow in a canine model
97. Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart
98. Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and arterial response to injury
99. Intracoronary basic fibroblast growth factor enhances myocardial collateral perfusion in dogs
100. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts
101. Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: A comparison of angiographic, echocardiographic, and coronary flow parameters
102. Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia
103. Effects of acidic fibroblast growth factor on normal and ischemic myocardium
104. Extracardiac to coronary anastomoses support regional left ventricular function in dogs
105. Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease: Preliminary clinical results
106. Intraoperative multiplane transesophageal echocardiography for guiding direct myocardial gene transfer of vascular endothelial growth factor in patients with refractory angina pectoris
107. Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs: Hibernation versus stunning?
108. Hibernating myocardium
109. Current diagnostic techniques of assessing myocardial viability in patients with hibernating and stunned myocardium
110. 165 gene transfer for therapeutic angiogenesis in chronic myocardial ischemia
111. Methods of local gene delivery to vascular tissues
112. Electromagnetic guidance for catheter-based transendocardial injection: A platform for intramyocardial angiogenesis therapy
113. Randomized, placebo-controlled clinical study of percutaneous catheter-based left ventricular endocardial gene transfer of VEGF-2 for myocardial angiogenesis in patients with chronic myocardial ischemia
114. Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: Results of a phase I randomized, double-blind, placebo-controlled trial
115. Therapeutic angiogenesis with basic fibroblast growth factor: Technique and early results
116. First angiogenic treatment of coronary heart disease by FGF-1: Long-term results after 3 years
117. Induction of myocardial neoangiogenesis by human growth factors. A new therapeutic option in coronary heart disease
118. Results of intracoronary recombinant human vascular endothelial growth factor (rhVEGF) administration trial
119. Final results of the VIVA trial of rhVEGF for human therapeutic angiogenesis
120. Meeting highlights: Highlights of the 48th Scientific Sessions of the American college of cardiology
121. VIVA trial: One-year follow-up
122. Results from late-breaking clinical trials sessions at ACCIS 2000 and ACC 2000
123. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery
124. 165 gene transfer
125. Stent endothelialization: Time course, impact of local catheter delivery, feasibility of recombinant protein administration, and response to cytokine expedition
126. 165 inhibits thrombus formation and intimal thickening
127. VEGF gene delivery to muscle: Potential role of vasculogenesis in adults
128. Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat: Aangiogenesis and angioma formation
129. Vascular endothelial growth factor in ocular fluids of patients with diabetic retinopathy and other retinal disorders
130. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-I
131. Vascular endothelial growth factor/vascular permeability factor produces nitric oxide-dependent hypotension
132. Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) augments nitric oxide release from quiescent rabbit and human vascular endothelium
133. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
134. Angiogenesis inhibitors endostatin and TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice
135. Arterial gene therapy for inhibiting restenosis in patients with claudication undergoing superficial femoral artery angioplasty
136. Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty
137. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo
138. Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia
139. Influence of vascular endothelial growth factor on diabetic retinopathy
140. Transmyocardial laser revascularisation in patients with refractory angina: A randomized controlled trial
141. Transmyocardial laser revascularisation compared with continued medical therapy for treatment of refractory angina pectoris: A prospective randomized trial
142. Comparison of transmyocardial revascularization with medical therapy in patients with refractory angina
143. Transmyocardial revascularization with a carbon dioxide laser in patients with end-stage coronary artery disease
144. 2 laser in patients with refractory angina pectoris: Clinical results from the Norwegian randomized trial