Determination of amphetamine and its metabolite p-hydroxyamphetamine in rat urine by reversed-phase high-performance liquid chromatography after dabsyl derivatization

Biomedical Chromatography

Volumn 15, Issue 7, 2001, Pages 452-456

  Soares, Maria Elisa ^a   Carvalho, Flix ^a   De Bastos, Maria Lourdes ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOIC ACID; BIOMOLECULES; BODY FLUIDS; CHLORINE COMPOUNDS; ENZYMATIC HYDROLYSIS; EXTRACTION; FORENSIC SCIENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

4-DIMETHYLAMINOAZOBENZENE; BIOLOGICAL SAMPLES; DERIVATIZATIONS; ENDOGENOUS COMPOUND; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; PARENT COMPOUNDS; PREFERRED ROUTES; RAT URINE; REVERSED-PHASE HIGH PERFORMANCE; SULFONYL CHLORIDES;

METABOLITES;

4 DIMETHYLAMINOAZOBENZENE; AMPHETAMINE; BENZENE DERIVATIVE; BENZOIC ACID; BENZYLMETHYLKETONE; DABSYL CHLORIDE; DRUG METABOLITE; HYDROXYAMPHETAMINE; ILLICIT DRUG; ORGANIC SOLVENT; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BEHAVIOR; BIOTRANSFORMATION; CLINICAL STUDY; CONTROLLED STUDY; DERIVATIZATION; DRUG ABUSE; DRUG CONCENTRATION; DRUG METABOLISM; DRUG MONITORING; DRUG TOXICITY; DRUG USE; EXTRACTION; FORENSIC MEDICINE; HUMAN; HYDROLYSIS; HYDROXYLATION; LIPOPHILICITY; MOLECULAR STABILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TECHNIQUE; TEMPERATURE; URINALYSIS;

EID: 0035172860     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.93     Document Type: Article

References (15)

1. Determination of d-amphetamine in biological samples using high-performance liquid chromatography after precolumn derivatization with ophthaldialdehyde and 3-mercaptopropionic acid
2. d-Amphetamine interaction with glutathione in freshly isolated rat hepatocytes
3. d-Amphetamine induced hepatotoxicity-a possible contribution of catecholamines and hyperthermia for this effect studied in isolated rat hepatocytes
4. Effect of d-amphetamine repeated administration on rat antioxidant defences
5. Quantification of amphetamine in urine: Solid-phase extraction, polymeric-reagent derivatization and reversed-phase high-performance liquid chromatography
6. On-line derivatization into precolumns for the determination of drugs by liquid chromatography and column switching: Determination of amphetamines in urine
7. Determination of amphetamine, methamphetamine and amphetamine-derived designer drugs or medicaments in blood and urine
8. Simultaneous determination of amino acids and biogenic amines by reversed-phase high-performance liquid chromatography of the dabsyl derivatives
9. Sensitive high-performance liquid chromatographic method for the determination of the three main metabolites of selegiline (L-deprenyl) in human plasma
10. Urinary excretion of amphetamine and 4′-hydroxyamphetamine by sprague dawley and dark agouti rats
11. An improved HPLC method for analysis of methamphetamine and its metabolites in plasma
12. Comparative study of different extractive procedures to quantify morphine in urine by HPLC-UV
13. Determination of stimulants in a single human hair sample by high-performance liquid chromatographic method with chemiluminescence detection