Signaling pathway of ciliary neurotrophic factor in neuroblastoma cell lines

Medical and Pediatric Oncology

Volumn 36, Issue 1, 2001, Pages 118-121

  Takada, Naoyuki ^a   Isogai, Eriko ^b   Kawamoto, Takemasa ^a   Nakanishi, Hiroko ^b   Todo, Satoru ^a   Nakagawara, Akira ^a  

^a CHIBA CANCER CENTER   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

CNTF; Jak STAT; MAPK; Neuroblastoma

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; GLYCOPROTEIN GP 130; INTERLEUKIN 6; JANUS KINASE 1; LEUKEMIA INHIBITORY FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTYROSINE; STAT PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL SURVIVAL; COMPLEX FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOLYSIS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NERVE CELL; NEUROBLASTOMA CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTIGENS, CD; BLOTTING, NORTHERN; CILIARY NEUROTROPHIC FACTOR; CYTOKINE RECEPTOR GP130; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, FOS; HUMANS; JANUS KINASE 1; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; MACROMOLECULAR SUBSTANCES; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; NEUROBLASTOMA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; RECEPTORS, CYTOKINE; RECEPTORS, OSM-LIF; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0035172321     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-911X(20010101)36:1<118::AID-MPO1028>3.0.CO;2-R     Document Type: Conference Paper

References (23)

1. Cholinergic neurotrophic factors: Intraocular distribution of trophic activity for ciliary neurons
2. Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy
3. Proliferation and differentiation of embryonic chick sympathetic neurons: Effects of ciliary neurotrophic factor
4. Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture
5. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130
6. The receptor for ciliary neurotrophic factor
7. LIFR-β and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor
8. IL-6-induced homodimegization of gp130 and associated activation of a tyrosine kinase
9. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6-β receptor components
10. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cyt0kines and growth factors
11. Leukemia inhibitory factor and ciliary neurotrophic factor increase activated Ras in a neuroblastoma cell line and in sympathetic neuron cultures
12. Ciliary neurotrophic factor coordinately activates transcription of neuropeptide genes in a neuroblastoma cell line
13. Differentiation effects of ciliary neurotrophic factor on human neuroblastoma cells
14. Ciliary neurotrophic factor stimulates the phosphorylation of two forms of STAT3 in chick ciliary ganglion neurons
15. Catecholamine metabolism in tissue culture cells of a neuroblastoma
16. Definition of a continuous human cell line derived from neuroblastoma
17. Characterization of human neuroblastoma cell lines established before and after therapy
18. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones
19. Identical expression of cell surface membrane antigens on 2 parent 18 cloned cell lines derived from 2 different neuroblastoma metastases of the same patients
20. Differential susceptibility of HLA class II antigens induced by γ-interferon in human neuroblastoma cell lines
21. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
22. Requirement for MAP kinase (ERK2) activity in interferon-α- and interferon-β-stimulated gene expression through STAT proteins