Generation of a humanised single chain Fv (ScFv) derived from the monoclonal Eric-1 recognising the human neural cell adhesion molecule

Medical and Pediatric Oncology

Volumn 36, Issue 1, 2001, Pages 243-246

  Rubie, Herv ^a,i   Plantaz, Dominique ^a   Coze, Carole ^b,i   Michon, Jean ^c   Frappaz, Didier ^d   Baranzelli, Marie Christine ^e   Chastagner, Pascal ^f   Peyroulet, Marie Cecile ^g,h  

^a U d'Hemato Oncol Pediat   (France)

^b Unit d'Hmato Oncologie Pediatrique   (France)

^c Unit d'Hmato Oncologie   (France)

^d INSTITUT CURIE   (France)

^e Centre Lon Brard   (France)

^f CENTRE OSCAR LAMBRET   (France)

^g Dpartment d'Oncologie Pdiatrique   (France)

^h INSTITUT GUSTAVE ROUSSY   (France)

ⁱ Unit d'Hmato Oncologie Pdiatrique Hpital des Enfants   (France)

Author keywords

Humanisation; Monoclonal antibodies; Neural cell adhesion molecule; ScFv

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; NERVE CELL ADHESION MOLECULE;

ANTIBODY RESPONSE; ANTIGEN BINDING; BINDING SITE; CELL INTERACTION; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; EMBRYO DEVELOPMENT; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR RECOGNITION; NEUROBLASTOMA; NEUROECTODERM TUMOR; PRIORITY JOURNAL; TARGET CELL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; BINDING, COMPETITIVE; DRUG DESIGN; EPITOPES; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MOLECULAR SEQUENCE DATA; NEURAL CELL ADHESION MOLECULES; NEUROBLASTOMA; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0035172277     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-911X(20010101)36:1<243::AID-MPO1060>3.0.CO;2-5     Document Type: Conference Paper

References (7)

1. A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognises the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm
2. Neural cell adhesion molecule: Structure, immunoglobulin-like domains, cell surface modulation and alternative RNA splicing
3. NCAM biosynthesis in brain
4. Use of panels of monoclonal antibodies in the differential diagnosis of neuroblastoma and lymphoblastic disorders
5. Magnetic microspheres and monoclonal antibodies for the depletion of neuroblastoma cells from bone marrow: Experiences, improvements and observations
6. Single-chain antigen-binding proteins
7. Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli