The Leishmania genome project: New insights into gene organization and function

Medical Microbiology and Immunology

Volumn 190, Issue 1-2, 2001, Pages 9-12

  Myler, Peter J ^a   Beverley, Stephen M ^b   Cruz, Angela K ^c   Dobson, Deborah E ^b   Ivens, Alasdair C ^d   McDonagh, Paul D ^a   Madhubala, Rentala ^e   Martinez Calvillo, Santiago ^a   Ruiz, Jeronimo C ^c   Saxena, Alka ^a   Sisk, Ellen ^a   Sunkin, Susan M ^a   Worthey, Elizabeth ^a   Yan, Shaofeng ^a   Stuart, Kenneth D ^a  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT ANTIGEN; TETRACYCLINE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME 1; CHROMOSOME 3; CHROMOSOME 4; CONTROLLED STUDY; DNA CONTENT; DNA STRAND; FLAGELLATE; GENE CLUSTER; GENE EXPRESSION; GENE FUNCTION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CONSERVATION; GENETIC ORGANIZATION; IMMUNIZATION; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; MOUSE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SERODIAGNOSIS; TELOMERE;

LEISHMANIA;

EID: 0035171871     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004300100070     Document Type: Article

References (24)

1. The complete chromosomal organization of the reference strain of the Leishmania genome project, L. major 'Friedlin'
2. Conserved linkage groups associated with large-scale chromosomal rearrangements between Old World and New World Leishmania genomes
3. Use of a cDNA microarray to analyse gene expression patterns in human cancer
4. Immunization with recombinant LD1 antigens protects against experimental leishmaniasis
5. Leishmania donovani: Characterization and expression of ORFF, a gene amplified from the LD1 locus
6. Proteome research: Complementarity and limitations with respect to the RNA and DNA worlds
7. A physical map of the Leishmania major Friedlin genome
8. The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1)
9. Exonic sequences in the 5′ untranslated region of alpha-tubulin mRNA modulate trans splicing in Trypanosoma brucei
10. A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA
11. Physical and transcriptional analysis of the Trypanosoma brucei genome reveals a typical eukaryotic arrangement with close interspersion of RNA polymerase II- and III-transcribed genes
12. A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes
13. The unusual gene organization of Leishmania major chromosome 1 may reflect novel transcription processes
14. The LD1 amplified element from Leishmania injantum encodes a homolog of ribosomal protein L37
15. An amplified DNA element in Leishmania encodes potential integral membrane and nucleotide binding proteins
16. A frequently amplified region in Leishmania contains a gene that is conserved in prokaryotes and eukaryotes
17. Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes
18. mRNA processing in the Trypanosomatidae
19. Serodiagnosis of leishmaniasis with recombinant ORFF antigen
20. High conservation of the fine-scale organisation of chromosome 5 between two pathogenic Leishmania species
21. The size difference between Leishmania major Friedlin chromosome one homologues is localized to sub-telomeric repeats at one chromosomal end
22. Temporal order of RNA-processing reactions in trypanosomes: Rapid trans splicing precedes polyadenylation of newly synthesized tubulin transcripts
23. The Leishmania genome comprises 36 chromosomes conserved across widely divergent human pathogenic species
24. Tetracycline regulated gene expression in Leishmania donovani