The type III secretion chaperone LcrH co-operates with YopD to establish a negative, regulatory loop for control of Yop synthesis in Yersinia pseudotuberculosis

Molecular Microbiology

Volumn 42, Issue 4, 2001, Pages 1075-1093

  Francis, M S ^a   Lloyd, S A ^a   Wolf Watz, H ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CHAPERONE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; LOW CALCIUM RESPONSE H PROTEIN; MUTANT PROTEIN; REGULATOR PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG; YERSINIA OUTER PROTEIN D;

ALLELE; ARTICLE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; CONTROLLED STUDY; GENE CONTROL; GENE TRANSLOCATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STABILITY; PROTEIN SYNTHESIS; REGULATORY MECHANISM; YERSINIA PSEUDOTUBERCULOSIS;

ANIMALS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; CELL DIVISION; HELA CELLS; HUMANS; MOLECULAR CHAPERONES; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENOTYPE; RECOMBINANT FUSION PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES; YERSINIA PSEUDOTUBERCULOSIS;

BACTERIA (MICROORGANISMS); EUKARYOTA; NEGIBACTERIA; YERSINIA; YERSINIA PSEUDOTUBERCULOSIS;

EID: 0035170435     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02702.x     Document Type: Article

References (88)

1. Reciprocal secretion of proteins by the bacterial type III machines of plant and animal pathogens suggests universal recognition of mRNA targeting signals
2. Substrate complexes and domain organization of the Salmonella flagellar export chaperones FlgN and FliT
3. From flagellum assembly to virulence: The extended family of type III export chaperones
4. Analysis of the V-antigen lcrGVH-YopBD operon of Yersinia pseudotuber-culosis: Evidence for a regulatory role of LcrH and LcrV
5. Molecular cloning of the temperature-inducible outer membrane protein 1 of Yersinia pseudotuberculosis
6. LcrQ/YscM1, regulators of the Yersinia Yop virulon, are injected into host cells by a chaperone-dependent mechanism
7. Coupling of flagellar gene expression to flagellar assembly in Salmonella enterica serovar Typhimurium and Escherichia coli
8. Yersinia pathogenicity factors
9. Assembly and function of type III secretory systems
10. Transcription of the yop regulon from Y. enterocolitica requires trans acting pYV and chromosomal genes
11. Homology between VirF, the transcriptional activator of the Yersinia virulence regulon, and AraC, the Escherichia coli arabinose operon regulator
12. Environmental control of virulence functions and signal transduction in Yersinia enterocolitica
13. The putative invasion protein chaperone SicA acts together with InvF to activate the expression of Salmonella typhimurium virulence genes
14. Type III secretion chaperone-dependent regulation: Activation of virulence genes by SicA and InvF in Salmonella typhimurium
15. A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis
16. The Yersinia pestis YscY protein directly binds YscX, a secreted component of the type III secretion machinery
17. High efficiency transformation of E. coli by high voltage electroporation
18. Bidirectional signaling between Yersinia and its target cell
19. Evidence for the secretion of Chlamydia trachomatis CopN by a type III secretion mechanism
20. LcrV of Yersinia pestis enters infected eukaryotic cells by a virulence plasmid-independent mechanism
21. Failure to detect binding of LcrH to the V antigen of Yersinia pestis
22. Virulence role of V-antigen of Yersinia pestis at the bacterial surface
23. The virulence protein Yop5 of Yersinia pseudotuberculosis is regulated at transcriptional level by plasmid-plB1-encoded trans-acting elements controlled by temperature and calcium
24. YopD of Yersinia pseudotuberculosis is translocated into the cytosol of HeLa epithelial cells: Evidence of a structural domain necessary for translocation
25. A study of the YopD-LcrH interaction from Yersinia pseudotuberculosis reveals a role for hydrophobic residues within the amphipathic domain of YopD
26. Substrate-specific binding of hook-associated proteins by FlgN and FliT, putative chaperones for flagellum assembly
27. The chaperone-like protein yerA of Yersinia pseudotuberculosis stabilizes YopE in the cytoplasm but is dispensible for targeting to the secretion loci
28. Functional conservation of the effector protein translocators PopB/YopB and PopD/YopD of Pseudomonas aeruginosa and Yersinia pseudotuberculosis
29. Type III secretion machines: Bacterial devices for protein delivery into host cells
30. Functional conservation among members of the Salmonella typhimurium InvA family of proteins
31. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity
32. A cloned Erwinia chrysanthemi Hrp (type III protein secretion) system functions in Escherichia coli to deliver Pseudomonas syringae Avr signals to plant cells and to secrete Avr proteins in culture
33. Studies on transformation of Escherichia coli with plasmids
34. Immunohistochemical and electron microscopic study of interaction of Yersinia enterocolitica serotype 0:8 with intestinal mucosa during experimental enteritis
35. Genetically manipulated virulence of Yersinia enterocolitica
36. Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells
37. Type III protein secretion systems in bacterial pathogens of animals and plants
38. Identification of SycN, YscX, and YscY, three new elements of the Yersinia Yop virulon
39. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
40. Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells
41. Translation/secretion coupling by type III secretion systems
42. Unravelling the mysteries of virulence gene regulation in Salmonella typhimurium
43. The bacterial flagellum: Reversible rotary propellor and type III export apparatus
44. Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S Flexneri
45. A novel suicide vector and its use in construction of insertion mutations: Osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR
46. Flagellin A is essential for the virulence of Vibrio anguillarum
47. Insertion of a Yop translocation pore into the macrophage plasma membrane by Y. enterocolitica: Requirement for translocators YopB and YopD, but not LcrG
48. Role of SycD, the chaperone of the Yersinia Yop translocators YopB and YopD
49. Phylogenetic analyses of the constituents of type III protein secretion systems
50. 2+ response
51. YopB of Yersinia enterocolitica is essential for YopE translocation
52. Yersinia pestis: Etiological agent of plague
53. Cell-surface-bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarised mechanism into the target cell
54. Modulation of virulence factor expression by pathogen target cell contact
55. The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation
56. Genetic analysis of essential plasmid determinants of pathogenicity in Yersinia pestis
57. lcrH, a gene necessary for virulence of Yersinia pestis and for the normal response of Y. pestis to ATP and calcium
58. 2+ response virulence genes
59. A novel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis shows extensive homology to YopH
60. Inhibition of phagocytosis in Yersinia pseudotuberculosis: A virulence plasmid-encoded ability involving the Yop2b protein
61. The cytotoxic protein YopE of Yersinia obstructs the primary host defence
62. Target cell contact triggers expression and polarised transfer of Yersinia YopE cytotoxin into mammalian cells
63. Functional conservation of the secretion and translocation machinery for virulence proteins of yersiniae, salmonellae and shigellae
64. The Xanthomonas Hrp type III system secretes proteins from plant and mammalian bacterial pathogens
65. The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD
66. Type III secretion systems in animal- and plant-interacting bacteria
67. A broad host range mobilisation system for in vivo genetic engineering: Transposon mutagenesis in Gram negative bacteria
68. Electron microscopic evidence for in vivo extracellular localisation of Yersinia pseudotuberculosis harbouring the pYV plasmid
69. LcrG, a secreted protein involved in negative regulation of the low-calcium response in Yersinia pestis
70. 2+ response, and virulence of Yersinia pestis
71. YscM1 and YscM2, two Yersinia enterocolitica proteins causing downregulation of Yop transcription
72. 2+ in Yersinia pestis include structural genes for outer membrane proteins
73. Environmental modulation of gene expression and pathogenesis in Yersinia
74. +2 response
75. Secretion of predicted Inc proteins of Chlamydia pneumoniae by a heterologous type III machinery
76. Yersinia enterocolitica type III secretion-translocation system: Channel formation by secreted Yops
77. Complex function for SicA, a Salmonella enterica serovar typhimurium type III secretion-associated chaperone
78. EspB and EspD require a specific chaperone for proper secretion from enteropathogenic Escherichia coli
79. SycE, a chaperone-like protein of Yersinia enterocolitica involved in the secretion of YopE
80. Individual chaperones required for Yop secretion by Yersinia
81. Customized secretion chaperones in pathogenic bacteria
82. YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops
83. Type III secretion systems and pathogenicity islands
84. Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon
85. 2+-blind mutants of Yersinia pestis
86. Temperature-controlled plasmid regulon associated with low calcium response in Yersinia pestis