Pharmacokinetic and pharmacodynamic analysis of the antihypercalcemic effect of incadronate disodium in rats

Biological and Pharmaceutical Bulletin

Volumn 24, Issue 11, 2001, Pages 1290-1293

  Ohno, Yoshiyuki ^a   Yamada, Yasuhiko ^a   Usui, Takashi ^b   Takahashi, Koichiro ^b   Tsuchiya, Fumito ^a   Ohtani, Hisakazu ^c   Sato, Hitoshi ^a   Sawada, Yasufumi ^c   Iga, Tatsuji ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b INSTITUTE FOR DEVELOPMENTAL RESEARCH   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Antihypercalcemic effect; Incadronate; Osteoclast; Pharmacodynamic; Pharmacokinetic; PK PD model

Indexed keywords

CALCIUM; INCADRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE; CALCIUM BLOOD LEVEL; CELL ACTIVITY; CELL MATURATION; CONTROLLED STUDY; DRUG EFFECT; DRUG TISSUE LEVEL; DRUG TRANSFORMATION; EXPERIMENTAL MODEL; HYPERCALCEMIA; INHIBITION KINETICS; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; RAT; TARGET ORGAN;

ANIMALS; BONE AND BONES; CALCIUM; CARCINOMA, SQUAMOUS CELL; DIPHOSPHONATES; HUMANS; HYPERCALCEMIA; INJECTIONS, INTRAVENOUS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOUTH NEOPLASMS; OSTEOCLASTS; RATS;

EID: 0035167936     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.24.1290     Document Type: Article

References (11)