Gene therapy-mediated expression by tumor cells of the angiogenesis inhibitor flk-1 results in inhibition of neuroblastoma growth in vivo

Journal of Pediatric Surgery

Volumn 36, Issue 1, 2001, Pages 30-36

  Davidoff, A M ^a   Leary, M A ^a   Ng, C Y C ^a   Vanin, E F ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Angiogenesis inhibition; flk 1; Gene therapy; Neuroblastoma; Vascular endothelial growth factor receptor

Indexed keywords

ANGIOGENESIS INHIBITOR; BASIC FIBROBLAST GROWTH FACTOR; GREEN FLUORESCENT PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2; VIRUS VECTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; GENE THERAPY; GENETIC ENGINEERING; HUMAN; HUMAN CELL; MOUSE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE; TUMOR GROWTH; TUMOR VASCULARIZATION;

EID: 0035166387     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1053/jpsu.2001.19998     Document Type: Article

References (25)

1. The role of angiogenesis in tumor growth
2. Mechanisms and therapeutic implications of angiogenesis
3. Tumor-associated angiogenesis: Mechanisms, clinical implications, and therapeutic strategies
4. Inhibition of angiogenesis
5. Anticancer strategies involving the vasculature: Vascular targeting and the inhibition of angiogenesis
6. Current approaches to targeting cancer using antiangiogenesis therapies
7. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
8. Role of VEGF-fit receptor system in normal and tumor angiogenesis
9. Failure of blood-island formation and vasculogenesis in Flk-1 deficient mice
10. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
11. Dominant-negative inhibition of flk-1 suppresses the growth of many tumor types in vivo
12. Flk-1 as a target for tumor growth inhibition
13. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
14. Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor
15. Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow
16. Analysis of mutation in human cells by using an Epstein Barr virus shuttle system
17. Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis
18. + progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors
19. An improved method for generating retroviral producer clones for vectors lacking a selectable marker gene
20. Inducible, high-level production of infectious murine leukemia retroviral vector particles pseudotyped with vesicular stomatitis Virus G envelope protein
21. Neuroblastoma: A clinical challenge and biologic puzzle
22. TNP-470 antiangiogenic therapy for advanced murine neuroblastoma
23. Angiostatic treatment of neuroblastoma
24. The angiogenesis inhibitor TNP-470 reduces the growth rate of human neuroblastoma in nude rats
25. Tumor angiogenesis correlates with metastatic disease, N-myc amplification, and poor outcome in human neuroblastoma