Transfection of nonmelanocytic cells with tyrosinase gene constructs for survival studies

Environmental and Molecular Mutagenesis

Volumn 38, Issue 2-3, 2001, Pages 216-222

  Ling, Angela Z ^a   Guyer, Robert B ^a   Deering, Reginald A ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

CHO; Melanin; UV

Indexed keywords

CARBON 14; COMPLEMENTARY DNA; MELANIN; MONOPHENOL MONOOXYGENASE; REACTIVE OXYGEN METABOLITE; TYROSINASE RELATED PROTEIN 1; TYROSINASE RELATED PROTEIN 2;

ANIMAL CELL; ARTICLE; CELL LINE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DNA VECTOR; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; GAMMA RADIATION; GENE EXPRESSION; GENETIC TRANSFECTION; NONHUMAN; PHOTON; QUANTITATIVE ASSAY; RADIOSENSITIVITY; SIGNAL DETECTION; ULTRAVIOLET B RADIATION; ULTRAVIOLET C RADIATION;

ANIMALS; CELL SURVIVAL; CRICETINAE; DNA DAMAGE; HUMANS; HYBRID CELLS; MELANINS; MONOPHENOL MONOOXYGENASE; RADIATION TOLERANCE; TRANSFECTION; ULTRAVIOLET RAYS;

EID: 0035166073     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.1074     Document Type: Article

References (53)

1. Comparison of the responses of human melanocytes with different melanin contents to ultra-violet B irradiation
2. Melanogenesis in transfected fibroblasts induces lysosomal activation
3. Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA
4. Survival of Cloudman mouse melanoma cells after irradiation by solar wavelengths of light
5. Free radicals in biological materials
6. Chemistry of melanins
7. Comparison of melanocytes and keratinocytes in ultraviolet-induced DNA damage per minimum erythema dose of sunlight: Applicability of ultraviolet action spectra for risk estimates
8. LipofectamineÔ reagent: A new, higher efficiency polycationic liposome transfection reagent
9. Invited editorial: Unraveling the melanocyte
10. Mammalian tyrosinase: A comparison of tyrosine hydroxylation and melanin formation
11. Mammalian tyrosinase - The critical regulatory control point in melanocyte pigmentation: Review
12. Melanotic Cloudman S91 mouse melanoma cells are more sensitive to UV and less sensitive to ionizing radiation killing than isogenic hypomelanotic cells
13. The function of melanin or six blind people examine an elephant
14. Is melanin photoprotective or is it photosensitizing?
15. UVA, pheomelanin and the carcinogenesis of melanoma
16. Comparative action spectra for pyrimidine dimer formation in Cloudman S91 mouse melanoma and EMT6 mouse mammary carcinoma cells
17. Ability of melanins to protect against the radiolysis of thymine and thymidine
18. Induction of DNA-protein crosslinks in melanotic Cloudman S91 mouse melanoma cells and EMT6 mouse mammary carcinoma cells by monochromatic 254 and 405 nm light
19. Does melanin affect low LET radiation response of Cloudman S91 mouse melanoma cell lines?
20. A multi-therapy resistance factor from melanoma reveals that killing by near UV is different from genotoxic agents
21. Comparative action spectrum for ultraviolet light killing of mouse melanocytes from different genetic coat color backgrounds
22. Melanin: A two edged sword? A review
23. Melanin photosensitizes UVC DNA damage in pigmented cells
24. A second tyrosine-related protein, TRP-2, maps to and is mutated at the mouse slaty locus
25. Mutagenesis and cytotoxicity in human epithelial cells by far and near ultraviolet radiation: Action spectra
26. Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesis
27. Pigmented cell lines of mouse albino melanocytes containing tyrosinase cDNA with an inducible promoter
28. On the etiology of vitiligo and gray hair
29. Melanin is a double-edged sword
30. Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain
31. Effects of UV radiation on cells
32. Ultraviolet B radiation was increased at ground level in Scotland during a period of ozone depletion
33. Resistance of pigmented human cells to killing by sunlight and oxygen radicals
34. Comparative studies on the correlation between pyrimidine dimer formation and tyrosinase activity in Cloudman S91 melanoma cells after ultraviolet-irradiation
35. 5,6-Dihydroxyindole is a melanin precursor showing potent cytotoxicity
36. Solar-ultraviolet-induced damage to DNA
37. Hydroxyl radical quenching agents protect against DNA breakage caused by both 365-nm UVA and by gamma radiation
38. Melanin
39. Free radical reduction in the human epidermis
40. Influence of an autocrine diffusible resistance factor on cell survival after exposure to therapeutic agents
41. Free radicals in melanin formation, structure and reactions
42. Eumelanins and pheomelanins: Characterisation by electron spin resonance spectroscopy
43. Wavelengths effective in induction of malignant melanoma
44. Tyrosinase transfection produces melanin synthesis and growth retardation in glioma cells
45. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter
46. Mutational mapping of the catalytic activities of human tyrosinase
47. Mutagenic action of monochromatic UV radiation in the solar range on human cells
48. Comparative analysis of hair melanins by chemical and electron spin resonance methods
49. Measurement of low levels of X-ray mutagenesis in relation to human disease
50. Expression of a mouse tyrosinase cDNA in 3T3 Swiss mouse fibroblasts
51. Fibroblasts expressing mouse c locus tyrosinase produce an authentic enzyme and synthesize phaeomelanin
52. What's the use of generating melanin?
53. Human TRP-1 has tyrosine hydroxylase activity but no dopa oxidase activity