Synthesis and purification of amyloidogenic peptides

Analytical Biochemistry

Volumn 288, Issue 1, 2001, Pages 76-82

  Nilsson, Melanie R ^a   Nguyen, Lan Lam ^b   Raleigh, Daniel P ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b Avon Products Inc   (United States)

Author keywords

Amylin; Amyloid; CD; HPLC; Peptide purification; Peptide synthesis

Indexed keywords

BIOSYNTHESIS; CHLORINE COMPOUNDS; GLYCOPROTEINS; ORGANIC SOLVENTS; PURIFICATION;

AMYLIN; AMYLOID; AMYLOIDOGENIC FRAGMENTS; AMYLOIDOGENIC PEPTIDES; HPLC; PEPTIDE SYNTHESIS; SOLID PHASE PEPTIDE SYNTHESIS; TYPE 2 DIABETES MELLITUS;

PEPTIDES;

9 FLUORENYLMETHYL CHLOROFORMATE; AMYLIN; AMYLOID; AMYLOID PRECURSOR PROTEIN; FLUORINE DERIVATIVE; N,N DIMETHYLFORMAMIDE; PHENOL; PYRROLIDINE DERIVATIVE; SYNTHETIC PEPTIDE; THIOL DERIVATIVE; TRIFLUOROACETIC ACID; WATER;

ARTICLE; CIRCULAR DICHROISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PURIFICATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0035161120     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2000.4887     Document Type: Article

References (11)

1. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
2. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
3. Identification and characterization of islet amyloid polypeptide in mammalian gastrointestinal tract
4. Molecular forms of islet amyloid polypeptide (IAPP/amylin) in four mammals
5. Islet amyloid polypeptide, a novel pancreatic peptide, is a circulating hormone secreted under glucose stimuliation
6. Analysis of amylin cleavage products provides new insights into the amyloidogenic region of human amylin