Modulation of human cytomegalovirus immediate-early gene enhancer by mitogen-activated protein kinase kinase kinase-1

Journal of Cellular Biochemistry

Volumn 83, Issue 4, 2001, Pages 563-573

  Sun, Bin ^a   Harrowe, Greg ^a   Reinhard, Christoph ^a   Yoshihara, Corinne ^a   Chu, Keting ^a   Zhuo, Shaoqiu ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

CREB; MAP kinases; NF B; PKA; Transcription regulation

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; ENHANCER REGION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMEDIATE EARLY GENE; IMMUNOBLOTTING; MUTAGENESIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; CELL LINE; CHO CELLS; CRICETINAE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYTOMEGALOVIRUS; ENHANCER ELEMENTS (GENETICS); GENE DELETION; GENES, IMMEDIATE-EARLY; GENETIC VECTORS; HUMANS; I-KAPPA B KINASE; IMMEDIATE-EARLY PROTEINS; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 1; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; RATS; REPRESSOR PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; UP-REGULATION; VIRAL ENVELOPE PROTEINS; VIRAL PROTEINS;

EID: 0035159733     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.1251     Document Type: Article

References (27)

1. Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer
2. Activation of proto-oncogenes: An immediate early event in human cytomegalovirus infection
3. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
4. Activation of stress-activated MAP protein kinases up-regulates expression of transgenes driven by the cytomegalovirus immediate/early promoter
5. The palindromic series I repeats in the simian cytomegalovirus major immediate-early promoter behave as both strong basal enhancers and cyclic AMP response elements
6. Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element
7. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
8. Regulation of human cytomegalovirus gene expression
9. Powerful and versatile enhancer-promoter unit for mammalian expression vectors
10. The promoter-regulatory region of the major immediate-early gene of human cytomegalovirus responds to T-lymphocyte stimulation and contains functional cyclic AMP-response elements
11. Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development
12. p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and fas expression
13. Inhibitory effect of 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole on HCMV DNA replication and permissive infection
14. Purification and activation of recombinant p38 isoforms alpha, beta, gamma, and delta
15. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
16. Regulation of human cytomegalovirus immediate-early gene expression
17. Phytohemagglutinin-induced activity of cyclic AMP (cAMP) response elements from cytomegalovirus is reduced by cyclosporine and synergistically enhanced by cAMP
18. Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection
19. Sigtrans;1999/5/re1. The NF-κB activation pathway: A paradigm in information transfer from membrane to nucleus
20. NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation
21. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
22. The TAO of MEKK
23. CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
24. Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation
25. Promoter-regulatory region of the major immediate early gene of human cytomegalovirus
26. I kappa B proteins: Structure, function, and regulation
27. Dominant negative regulation by c-Jun of transcription of the uncoupling protein-1 gene through a proximal cAMP-regulatory element: A mechanism for repressing basal and norepinephrine-induced expression of the gene before brown adipocyte differentiation