Manipulating the in vivo mRNA expression profile of FSHβ to resemble that of LHβ does not promote a concomitant increase in intracellular storage of follicle-stimulating hormone

Journal of Neuroendocrinology

Volumn 13, Issue 1, 2001, Pages 50-62

  Brown, Pamela ^a   McNeilly, J R ^a   Evans, J G ^a   Crawford, G M ^a   Walker, M ^a   Christian, H C ^b   McNeilly, A S ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

FSH; FSH mRNA; LH mRNA; Transgenic mice

Indexed keywords

ACTIVIN; BRAIN EXTRACT; COMPLEMENTARY DNA; DACTINOMYCIN; ETHIDIUM BROMIDE; FOLLISTATIN; FOLLITROPIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GONADORELIN; GONADOTROPIN; INHIBIN; LUTEINIZING HORMONE; MESSENGER RNA; RIBONUCLEASE; STEROID;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CASTRATION; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; FOLLITROPIN RELEASE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC CODE; GLYCOSYLATION; HORMONAL REGULATION; HORMONE DETERMINATION; HYPOPHYSIS; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROMOTER REGION; RADIOIMMUNOASSAY; RNA TRANSCRIPTION; STEADY STATE; TISSUE CULTURE; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; ESTRUS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FOLLICLE STIMULATING HORMONE; FOLLICLE STIMULATING HORMONE, BETA SUBUNIT; GENE EXPRESSION; INHIBINS; LUTEINIZING HORMONE; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; ORCHIECTOMY; OVARIECTOMY; OVULATION; PITUITARY GLAND; RNA, MESSENGER; SHEEP; TRANSGENES;

EID: 0035159448     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2001.00594.x     Document Type: Article

References (35)

1. Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotroph cell line
2. Transcriptional activation of the ovine follicle stimulating hormone β-subunit gene by gonadotropin-releasing hormone: Involvement of two activating protein-1-binding sites and protein kinase C
3. L beta T2 gonadotroph cells secrete follicle stimulating hormone (FSH) in response to activin A
4. 17β-estradiol and progesterone inhibit transcription of the genes encoding the subunits of ovine follicle-stimulating hormone
5. Transcription rate of the follicle stimulating hormone (FSH) β subunit gene is reduced by inhibin in sheep but this does not fully explain the decrease in mRNA
6. Decay of follicle-stimulating hormone-β messenger RNA in the presence of transcriptional inhibitors and/or inhibin, activin or follistatin
7. Differential stability of mRNAs coding for α and gonadotropin β subunits in cultured rat pituitary cells
8. Human luteinizing hormone and chorionic gonadotrophin are targeted to a regulated secretory pathway in GH3 cells
9. 3 cells: Evidence for separate secretory pathways
10. Gonadotrophin secretion revisited. How many ways can FSH leave a gonadotroph?
11. The control of FSH secretion
12. Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumours
13. Luteinizing hormone induction of ovarian tumours: Oligogenic differences between mouse strains dictates tumor disposition
14. Gonadal steroid hormone regulation of human and mouse follicle stimulating hormone β-subunit gene expression in vivo
15. Gonadotroph-specific expression of the human follicle-stimulating hormone β-gene in pituitaries of transgenic mice
16. Genetic rescue of follicle-stimulating hormone β-deficient mice
17. Transgenic models to study gonadotropin function: The role of follicle-stimulating hormone in gonadal growth and tumorigenesis
18. Characterization of the ovine LHβ-subunit gene: The promoter is regulated by GnRH and gonadal steroids in transgenic mice
19. Removal of 3′ untranslated sequences dramatically enhances transient expression of ovine follicle-stimulating hormone beta gene messenger ribonucleic acid
20. Control of messenger RNA stability in higher eukaryotes
21. Characterization of the ovine LHβ-subunit gene: The promoter directs gonadotroph-specific expression in transgenic mice
22. Steroidogenic factor-1 (SF-1) and the regulation of expression of luteinising hormone and follicle stimulating hormone b-subunits in the sheep anterior pituitary in vivo
23. Theory and practise of stereological techniques applied to the estimation of cell number and nuclear volume in the testis
24. Development and application of a heterologous radioimmunoassay for ovine follicle-stimulating hormone
25. Follicle-stimulating hormone beta subunit messenger ribonucleic acid concentrations during the rat estrous cycle
26. Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone
27. Inhibin A and inhibin B are inversely correlated to follicle-stimulating hormone, yet are discordant during the follicular phase of the rat estrous cycle, and inhibin A is expressed in a sexually dimorphic manner
28. Differential sorting of lutropin and the free α-subunit in cultured bovine pituitary cells
29. Pituitary glycoprotein hormone oligosaccharides: Structure, synthesis and function of the asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin
30. Both of the β-subunit carbohydrate residues of follicle-stimulating hormone determine the metabolic clearence rate and in vivo potency
31. Biosynthesis and secretion of follicle-stimulating hormone
32. Fetal testis - A very special endocrine organ
33. Regulation of spermatogenesis
34. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
35. A model for follicular selection and ovulation: Lessons from superovulation