Streptococcal preparation OK-432 enhances the antitumor activity of CPT-11 by increasing Th1-cytokine production in mice

Anticancer Research

Volumn 21, Issue 4 A, 2001, Pages 2505-2510

  Wang, X ^a   Fujimoto, T ^a   Zhang, B ^a   Mai, M ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

IL 12; Irinotecan (CPT 11); OK 432; SN 38; Th1 cytokine

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 6; IRINOTECAN; PICIBANIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL LEVEL; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENTIATION; EVALUATION; FEMALE; MACROPHAGE; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STREPTOCOCCUS PYOGENES; TH1 CELL;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; FEMALE; INTERFERON TYPE II; INTERLEUKIN-12; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; PICIBANIL; SPLEEN; TH1 CELLS;

EID: 0035157337     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. A pilot study of combination therapy of radiation and local administration of OK-432 for esophageal cancer
2. Intratumoral injection of a streptococcal preparation, OK-432, before surgery for gastric cancer
3. Postoperative immunochemotherapy including streptococcal lysate OK-432 is effective for patients with gastric cancer and serosal invasion
4. Augmentation of mouse natural killer cell activity by a streptococcal preparation, OK-432
5. Streptococcal preparation OK-432 is a potent inducer of IL-12 and a T helper cell 1 dominant state
6. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
7. Phase II study of irinotecan combined with cisplatin in patients with previously untreated small-cell lung cancer
8. Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients
9. Phase I study of irinotecan combined with carboplatin in previously untreated solid cancers
10. Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages
11. Antitumor and antimetastatic activity of interleukin 12 against murine tumors
12. Bacillus Calmette-Guerin plus interleukin-2 and/or granulocyte/macrophage-colony-stimulating factor enhances immunocompetent cell production of interferon-γ, which inhibits B16F10 melanoma cell growth in vitro
13. Regulatory mechanisms for production of IFN-γ and TNF by antitumor T cells or macrophages in the tumor-bearing state
14. Cellular basis for adriamycin-induced augmentation of cell-mediated cytotoxicity in culture
15. Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11
16. Cyclophosphamide-faciliated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells
17. Reciprocal control of T helper cell and dendritic cell differentiation