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Volumn 59, Issue 1, 2001, Pages 49-58
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Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: A mathematical construct
a,b
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Author keywords
5 fluorouracil (5 FU); Biologically based dose response model; Deoxyribonucleotide triphosphate (dNTP) pool perturbation; Fetal weight deficit; Thymidylate synthetase (TS) inhibition
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Indexed keywords
ADENOSINE DIPHOSPHATE;
ANTINEOPLASTIC AGENT;
CYTIDINE DIPHOSPHATE;
DEOXYADENOSINE TRIPHOSPHATE;
DEOXYCYTIDINE TRIPHOSPHATE;
DEOXYGUANOSINE TRIPHOSPHATE;
DEOXYRIBONUCLEOTIDE;
DEOXYURIDINE PHOSPHATE;
DNA;
DNA POLYMERASE;
FLOXURIDINE DERIVATIVE;
FLOXURIDINE PHOSPHATE;
FLUOROURACIL;
FLUOROURIDINE;
FOLIC ACID;
GUANOSINE DIPHOSPHATE;
PHOSPHATE;
RIBONUCLEOTIDE;
RIBONUCLEOTIDE REDUCTASE;
THYMIDINE;
THYMIDINE TRIPHOSPHATE;
THYMIDYLATE SYNTHASE;
URIDINE DIPHOSPHATE;
URIDINE PHOSPHATE;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ARTICLE;
CONTROLLED STUDY;
DATA ANALYSIS;
DEVELOPMENTAL DISORDER;
DISEASE MODEL;
DNA FLANKING REGION;
DOSE RESPONSE;
DRUG ACTIVITY;
DRUG METABOLISM;
DRUG TOLERABILITY;
EMBRYO;
ENZYME ACTIVITY;
ENZYME ANALYSIS;
ENZYME INHIBITION;
FEMALE;
FETUS;
FETUS WEIGHT;
GESTATIONAL AGE;
MATHEMATICAL MODEL;
MOUSE;
NONHUMAN;
PREGNANCY;
REGULATORY MECHANISM;
RISK ASSESSMENT;
ABNORMALITIES, DRUG-INDUCED;
ANIMALS;
AREA UNDER CURVE;
DEOXYRIBONUCLEOTIDES;
DOSE-RESPONSE RELATIONSHIP, DRUG;
EMBRYO;
EMBRYONIC AND FETAL DEVELOPMENT;
ENZYME INHIBITORS;
FEMALE;
FETAL WEIGHT;
FLUOROURACIL;
INJECTIONS, SUBCUTANEOUS;
MODELS, BIOLOGICAL;
PREGNANCY;
RATS;
RATS, SPRAGUE-DAWLEY;
RISK ASSESSMENT;
TERATOGENS;
THYMIDYLATE SYNTHASE;
ANIMALIA;
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EID: 0035154364
PISSN: 10966080
EISSN: None
Source Type: Journal
DOI: 10.1093/toxsci/59.1.49 Document Type: Article |
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Times cited : (26)
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References (27)
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