Proteinuria and plasma compositional changes contribute to defective lipoprotein catabolism in the nephrotic syndrome by separate mechanisms

American Journal of Kidney Diseases

Volumn 37, Issue 1 SUPPL. 2, 2001, Pages

  Shearer, Gregory C ^a   Kaysen, George A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endothelium; Lipoprotein binding; Lipoprotein lipase; Proteinuria; Serum albumin concentration; Very low density lipoprotein (VLDL)

Indexed keywords

LIPOPROTEIN; LIPOPROTEIN LIPASE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL MODEL; CATABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTHELIUM CELL; HYPERLIPIDEMIA; NEPHROTIC SYNDROME; NONHUMAN; ONCOTIC PRESSURE; PROTEIN BINDING; PROTEINURIA; RAT; RAT STRAIN;

EID: 0035149949     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/ajkd.2001.20766     Document Type: Conference Paper

References (16)

1. Mechanisms and consequences of proteinuria
2. Plasma alpha 2 macroglobulin is increased in nephrotic patients as a result of increased synthesis alone
3. Proportionate increase of fibrinogen and albumin synthesis in nephrotic patients. Measurements with stable isotopes
4. Evidence for increased synthesis of lipoprotein(a) in the nephrotic syndrome
5. Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL results from increased synthesis
6. Transferrin metabolism in the nephrotic syndrome and in protein-losing gastroenteropathy
7. Effect of dietary protein intake on albumin homeostasis in nephrotic patients
8. Proteinuria, not altered albumin metabolism, affects hyperlipidemia in the nephrotic rat
9. Detective lipolysis persists in hearts of rats with Heymann nephritis in the absence of nephrotic plasma
10. Precautionary measures for collecting blood destined for lipoprotein isolation
11. Endothelial binding sites for lipoprotein lipase are not diminished in perfused hearts from diabetic rats
12. Isolation of rat aotric endothelial cells by primary explant techniques and their phenotypic modulation by defined substrata
13. I-131-labeling of proteins by the iodine monochloride method
14. Improvement of lipid abnormalities associated with proteinuria using fosinopril, an angiotensin-converting enzyme inhibitor
15. Gene expression of lipoprotein lipase in experimental nephrosis
16. Symptomatic antiproteinuric treatment decreases serum lipoprotein (a) concentration in patients with glomerular proteinuria