Positive and negative intronic regulatory elements control muscle-specific alternative exon splicing of Drosophila myosin heavy chain transcripts

Genetics

Volumn 157, Issue 1, 2001, Pages 259-271

  Standiford, David M ^a   Sun, Wei Tao ^a   Davis, Mary Beth ^a   Emerson Jr , Charles P ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRACTILE PROTEIN; MYOSIN HEAVY CHAIN;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENHANCER REGION; EXON; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; INTRON; MUSCLE DEVELOPMENT; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPRESSOR GENE; SPLICEOSOME;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CONSERVED SEQUENCE; DNA; DNA PRIMERS; DROSOPHILA; EXONS; GENES, INSECT; GENES, REGULATOR; INTRONS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUSCLES; MYOSIN HEAVY CHAINS;

ARACHNIDA; HEXAPODA;

EID: 0035148429     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

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2. Fine tuning a molecular motor: The location of alternative domains in the Drosophila myosin head
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4. Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene
5. Determination of an RNA structure involved in splicing inhibition of a muscle-specific exon
6. Transposable element insertions respecify alternative exon splicing in three Drosophila myosin heavy chain mutants
7. Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: Visualization of the pre-power stroke state
8. Protein phosphorylation plays an essential role in the regulation of alternative splicing and sex determination in Drosophila
9. Enhancer elements activate the weak 3′ splice site of alpha-tropomyosin exon 2
10. The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A
11. Functional domains of the Drosophila melanogaster muscle myosin heavy-chain gene are encoded by alternatively spliced exons
12. CA- and purine-rich elements form a novel bipartite exon enhancer which governs inclusion of the minute virus of mice NS2-specific exon in both singly and doubly spliced mRNAs
13. Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon
14. Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated α-tropomyosin exon
15. Myosin functional domains encoded by alternative exons are expressed in specific thoracic muscles of Drosophila
16. Suboptimal 5′ and 3′ splice sites regulate alternative splicing of Drosophila melanogaster myosin heavy chain transcripts in vitro
17. The role of evolutionarily conserved sequences in alternative splicing at the 3′ end of Drosophila melanogaster myosin heavy chain RNA
18. Recognition of exonic splicing enhancer sequences by the Drosophila splicing repressor RSF1
19. Tissue-specific splicing in vivo of the beta-tropomyosin gene: Dependence on RNA secondary structure
20. Regulation of alternative 3′ splice site selection by constitutive splicing factors
21. Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins
22. Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3′-terminal exon
23. Interspecific sequence comparison of the muscle-myosin heavy-chain genes from Drosophila hydei and Drosophila melanogaster
24. Alpha-tropomyosin mutually exclusive exon selection: Competition between branchpoint/polypyrimidine tracts determines default exon choice
25. Alternative splicing is an efficient mechanism for the generation of protein diversity: Contractile protein genes as a model system
26. Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55
27. Characterization and molecular cloning of polypyrimidine tract-binding protein: A component of a complex necessary for pre-mRNA splicing
28. Mutation of PTB binding sites causes misregulation of alternative 3′ splice site selection in vivo
29. A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer
30. Exon definition may facilitate splice site selection in RNAs with multiple exons
31. Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle
32. Selection and characterization of pre-mRNA splicing enhancers: Identification of novel SR protein-specific enhancer sequences
33. Polypyrimidine tract binding protein functions as a repressor to regulate alternative splicing of alpha-actinin mutually exclusive exons
34. Splice-junction elements and intronic sequences regulate alternative splicing of the Drosophila myosin heavy chain gene transcript
35. The relative strengths of SR protein-mediated associations of alternative and constitutive exons can influence alternative splicing
36. Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2
37. The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element
38. A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly