Assessment of the antitumour activity of targeted immunospecific albumin microspheres loaded with cisplatin and 5-fluorouracil: Toxicity against a rodent ovarian carcinoma in vitro

Cell Biology International

Volumn 25, Issue 1, 2001, Pages 51-59

  Truter, Ernest J ^a   Santos, Aldina S ^a   Els, Willem J ^b  

^a CAPE PENINSULA UNIVERSITY OF TECHNOLOGY   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Cytotoxicity; Microspheres; Ovarian cancer; Targeted drug delivery

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALBUMIN; CISPLATIN; FLUOROURACIL; MICROSPHERE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG FORMULATION; DRUG TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROENCAPSULATION; NONHUMAN; OVARY CARCINOMA; RODENT;

RODENTIA;

EID: 0035147521     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1006/cbir.2000.0677     Document Type: Article

References (23)

1. Murine monoclonal antibodies
2. Platinum complexes in cancer medicine: Pharmacokinetics and pharmacodynamics in relation to toxicity and therapeutic activity
3. Study on cisplatin albumin microspheres for neck external artery embolization
4. Rapid colorimetric assay for cell growth and survival
5. Selective delivery of 5-flourouracil (5-FU) to i.p. tissues using 5-FU microspheres in rats
6. Drug interactions of 5-fluorouracil with either cisplatin or lobaplatin - A new, clinically active platinum analog in established human cancer cell lines
7. Attachment of monoclonal antibodies to microspheres
8. Establishment and morphologic characterization of cell line (DMBA-OC-1) from 7, 12-dimethylbenz (a) anthracene-induced rat ovarian carcinoma
9. Sterically stabilized anti-HER2 immunoliposomes: Design and targeting to human breast cancer cells in vitro
10. Toxicity of a particulate formulation for the intraperitoneal application of mitoxantrone
11. Determination of platinum in plasma of patients affected by inoperable lung carcinoma treated with radiation and concurrent low-dose infusion of cis-dichlorodiammine platinum (II)
12. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
13. New therapy for ovarian cancer
14. Site-specific (targeted) drug delivery in cancer therapy
15. Biological approaches to the controlled delivery of drugs: A critical review
16. Improved complete response rates and survival in advanced head and neck cancer after three-course induction therapy with 120 hours 5-FU infusion and cisplatin
17. Cis-dichlorodiammineplatinum (II): Combination chemotherapy and cross-resistance studies with tumours of mice
18. Studies on succinate-tetrazolium reductase systems. III. Points of coupling four different tetrazolium salts
19. Heat-stabilised albumin microspheres as a sustained drug delivery system for the anti-metabolite, 5-fluorouracil
20. Albumin microspheres: Heat and chemical stabilisation