Activation of nuclear factor-κB and its suppression by dexamethasone in polymorphonuclear leukocytes: Newborn versus adult

Pediatric Research

Volumn 49, Issue 2, 2001, Pages 257-262

  Vancurova, I ^a   Bellani, P ^a   Davidson, D ^a  

^a LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; DIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; COMPARATIVE STUDY; CYTOKINE RELEASE; DRUG INHIBITION; ELECTROPHORETIC MOBILITY; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; INFLAMMATION; NEUTROPHIL; NEWBORN; PRIORITY JOURNAL;

EID: 0035146546     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200102000-00021     Document Type: Article

References (41)

1. Neutrophils in human diseases
2. Macrophages and polymorphonuclear neutrophils in lung defense and injury
3. Interleukin-1 production by human polymorphonuclear neutrophils
4. Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor
5. Cytokine-induced neutrophil-derived interleukin-8
6. Cytokine expression and release by neutrophils
7. IFN-gamma is produced by polymorphonuclear neutrophils in human uterine endometrium and by cultured peripheral blood polymorphonuclear neutrophils
8. Mechanism for dexamethasone inhibition of neutrophil migration upon exposure to lipopolysaccharide in vitro: Role of neutrophil interleukin-8 release
9. Nuclear factor-κB-a pivotal transcription factor in chronic inflammatory diseases
10. The role of nuclear factor-κB in cytokine gene regulation
11. Nuclear factor κB: A pivotal role in the systemic inflammatory response syndrome and new target for therapy
12. Structure, regulation, and function of NF-κB
13. Activation of the NF-κB pathway by inflammatory stimuli in human neutrophils
14. Interleukin-15 induces NF-κB activation and IL-8 production in human neutrophils
15. NF-κB activation is a critical regulator of human granulocyte apoptosis in vitro
16. Selective activation and functional significance of 38α mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
17. Comparative differences and combined effects of interleukin-8, leukotriene B4, and platelet-activating factor on neutrophil chemotaxis of the newborn
18. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
19. A DNA-activated protein kinase from HeLa cell nuclei
20. The oncoprotein Bcl-3 can facilitate NF-κB mediated transactivation by removing inhibiting p50 homodimers from select κB sites
21. Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-κB p50
22. Tolerance to lipopolysaccharide involves mobilization of nuclear factor κB with predominance of p50 homodimers
23. NF-κB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression
24. Elevated interleukin-1 expression in human neonatal neutrophils
25. The beginning of the end: IκB kinase (IKK) and NF-κB activation
26. Control of NF-κB transcriptional activation by signal induced proteolysis of IκBα
27. Nuclear retention of IκBα protects it from signal-induced degradation and inhibits NF-κB transcriptional activation
28. Signals leading to the activation of NF-κB transcription factor are stronger in neonatal than adult T lymphocytes
29. Spontaneous and Fas-mediated apoptosis are diminished in umbilical cord blood neutrophils compared with adult neutrophils
30. Clinical trials of postnatal corticosteroids: Inhaled and systemic
31. Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of broncho-pulmonary dysplasia
32. Regulation of neutrophil-derived IL-8: The role of prostaglandin E2, dexamethasone, and IL-4
33. Molecular mechanisms of anti-inflammatory action of glucocorticoids
34. Molecular mechanisms of immunosuppresssion and anti-inflammatory activities by glucocorticoids
35. A dual mechanism mediates repression of NF-κB activity by glucocorticoids
36. Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis
37. Role of transcriptional activation of IκB in mediation of immunosuppression by glucocorticosteroids
38. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor
39. Glucocorticoid-mediated repression of NF-κB activity in endothelial cells does not involve induction of IκBα synthesis
40. A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of ReIA transactivation
41. IκBα-independent downregulation of NF-κB activity by glucocorticoid receptor