Mutation of amino acids 566-572 (KKKVLDK) inhibits nuclear accumulation of heat shock protein 72 after heat shock

Journal of Molecular and Cellular Cardiology

Volumn 33, Issue 1, 2001, Pages 49-55

  Knowlton, A A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Heat shock proteins; HSP70; Nuclear localization signal; Nucleolus

Indexed keywords

HEAT SHOCK PROTEIN 72; HYBRID PROTEIN;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL VIABILITY; GENE MUTATION; HEAT SHOCK; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOLUS; PRIORITY JOURNAL;

EID: 0035145955     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1274     Document Type: Article

References (18)

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3. Late preconditioning against myocardial stunning: An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs
4. Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells
5. Structure and expression of the human gene encoding major heat shock protein HSP 70
6. Mutation of amino acids 246-251 alters nuclear accumulation of human heat shock protein (HSP) 72 with stress, but does not reduce viability
7. Depolarization-transcription signals in skeletal muscle use calcium flux through L channels, but bypass the sarcoplasmic reticulum
8. Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia
9. A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit heart
10. Phosphorylation at tyrosine 524 influences nuclear concentration of HSP 72 with stress
11. Genetic sequence data bank
12. Mutational analysis of the human HSP70 protein: Distinct domains for nucleolar localization and adenosine triphosphate binding
13. Evidence for the existence of a novel mechanism for the nuclear import of HSC 70
14. Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins
15. The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate
16. Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and Simian virus 40 large tumor antigen
17. Identification of nuclear and nucleolar localization signals in the herpes simplex virus regulatory protein ICP27