Effect of hypothermia on the hepatic uptake and biliary excretion of vecuronium in the isolated perfused rat liver

Anesthesiology

Volumn 94, Issue 2, 2001, Pages 270-279

  Beaufort, Ton M ^a,b   Proost, Johannes H ^a   Maring, Jan Gerard ^a   Scheffer, Emiel R ^a   Wierda, J Mark K H ^a   Meijer, Dirk K F ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

VECURONIUM;

ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; DRUG CLEARANCE; DRUG ELIMINATION; HYPOTHERMIA; ISOLATED LIVER; LIVER METABOLISM; LIVER PERFUSION; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE LEVEL;

EID: 0035144691     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200102000-00017     Document Type: Article

References (39)

1. The effect of temperature on a d-tubocurarine neuromuscular blockade and its antagonism by neostigmine
2. Pancuronium-induced neuromuscular blockade, and its antagonism by neostigmine at 29, 37 and 41°C
3. Hypothermia and the pharmacokinetics and pharmacodynamics of pancuronium in the cat
4. Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in the cat
5. Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in humans
6. Hypothermic cardiopulmonary bypass and neuromuscular blockade by pancuronium and vecuronium
7. Vecuronium and atracurium infusions during hypothermic cardiopulmonary bypass
8. The effect of peripheral hypothermia on a vecuronium-induced neuromuscular block
9. Mild intra-operative hypothermia increases duration of action and spontaneous recovery of vecuronium blockade during nitrous oxide-isoflurane anesthesia in humans
10. Greater neuromuscular blocking potency of atracurium during hypothermic than during normothermic cardiopulmonary bypass
11. Unequal effects of cardiopulmonary bypass-induced hypothermia on neuromuscular blockade from constant infusion of alcuronium, d-tubocurarine, pancuronium, and vecuronium
12. Iontophoretic study of speed of action of various muscle relaxants
13. Inhibition of the enzymatic degradation of suxamethonium and mivacurium increases the onset time of submaximal neurmomuscular block
14. 3H
15. Comparative pharmacokinetics of d-tubocurarine and metocurine in man
16. Effects of hepatic uptake of vecuronium bromide and its putative metabolites on their neuromuscular blocking actions in the cat
17. Disposition of vecuronium bromide in the cat
18. Hepatobiliary disposition of vecuronium bromide in man
19. Disposition and urinary excretion of vecuronium bromide in anesthetized patients with normal renal function or renal failure
20. Isolated perfused liver technique
21. Pharmacokinetics of steroidal muscle relaxants in isolated perfused rat liver
22. Uptake and excretion of vecuronium bromide and pancuronium bromide in the isolated perfused rat liver
23. Protein measurement with the Folin phenol reagent
24. Determination of rocuronium and its putative metabolites in body fluids and tissue homogenates
25. Relationship between chemical structure and physicochemical properties of series of bulky organic cations and their hepatic uptake and biliary excretion rates
26. Transport of drugs
27. The mechanism for hepatic uptake and biliary excretion of organic cations
28. Current concepts on hepatic transport of drugs
29. Transport and metabolism in the hepatobiliary system
30. Transport of endogenous and exogenous organic cations
31. A multispecific uptake system for taurocholate, cardiac glycosides and cationic drugs in the liver
32. Hepatic transport mechanism for bivalent organic cations: Subcellular distribution and hepato-biliary concentration gradients of some steroidal muscle relaxants
33. Differential effects of metabolic inhibitors on cellular and mitochondrial uptake of organic cations in the rat liver
34. Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations
35. Mechanisms for the hepatic uptake of organic cations: Studies with the muscle relaxant vecuronium in isolated rat hepatocytes
36. Mechanisms for the uptake of cationic drugs by the liver: A study with tributylmethylammonium (TBuMA)
37. Hepatobiliary elimination of cationic drugs: The role of P-glycoproteins and other ATP-dependent transporters
38. Interactions between P-glycoprotein substrates and cationic drugs at the hepatic excretory level