Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels

Biophysical Journal

Volumn 80, Issue 2, 2001, Pages 707-718

  Slesinger, Paul A ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; ION; LIDOCAINE; LIDOCAINE ETHOBROMIDE; LOCAL ANESTHETIC AGENT; MUTANT PROTEIN; N [(2,6 DIMETHYLPHENYL)CARBAMOYLMETHYL]TRIMETHYLAMMONIUM; POTASSIUM CHANNEL; POTASSIUM ION;

ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CHIMERA; COMPLEX FORMATION; CONTROLLED STUDY; FILTER; GENE MUTATION; HYDROPHOBICITY; NONHUMAN; POTASSIUM CURRENT; PROTEIN DOMAIN;

ANIMALIA;

EID: 0035144502     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(01)76050-X     Document Type: Article

References (7)

1. Adams, C. M., M. P. Price, P. M. Snyder, and M. J. Welsh. 1999. Tetraethylammonium block of the BNC1 channel. Biophys. J. 76: 1377-1383.
2. Alreja, M., and G. K. Aghajanian. 1994. QX-314 blocks the potassium but not the sodium-dependent component of the opiate response in locus coeruleus neurons. Brain Res. 639:320-324.
3. + conductance by QX-314 in the rat hippocampus. Eur. J. Pharmacol. 199:259-262.
4. + channel. Science. 271:653-656.
5. + channel subunit. Proc. Natl. Acad. Sci. USA. 93:14193-14198.
6. Choe, S., C. F. Stevens, and J. M. Sullivan. 1995. Three distinct structural environments of a transmembrane domain in the inwardly rectifying potassium channel ROMK1 defined by perturbation. Proc. Natl. Acad. Sci. USA. 8292:12046-12049.
7. ir2.1, an inward rectifier potassium channel. Proc. Natl. Acad. Sci. USA. 94: 5446-5460.