Rate and equilibrium constants for the epimerization of the endothelin receptor antagonist J-104,132 in aqueous solution

Chemical and Pharmaceutical Bulletin

Volumn 49, Issue 1, 2001, Pages 1-4

  Bray, M L ^a   Gorbacheva, D ^a   Jahansouz, H ^a   Kaufman, M J ^a   Ishikawa, K ^a   Harada, N ^a   Suzuki, K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Endothelin receptor antagonist; Epimerization; Equilibrium; Kinetics; Preformulation; Stability

Indexed keywords

2 BUTYL 7 [2 (2 CARBOXYPROPYL ) 4 METHOXYPHENYL] 5 (3,4 METHYLENEDIOXYPHENYL)CYCLOPENTENO[1,2 B]PYRIDINE 6 CARBOXYLIC ACID; ENDOTHELIN RECEPTOR ANTAGONIST;

AQUEOUS SOLUTION; ARTICLE; DRUG STABILITY; PH; PREFORMULATION; TEMPERATURE;

HYDROGEN-ION CONCENTRATION; KINETICS; MOLECULAR CONFORMATION; PYRIDINES; RECEPTORS, ENDOTHELIN; SPECTRUM ANALYSIS; TEMPERATURE;

EID: 0035144072     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.49.1     Document Type: Article

References (12)