The nicotinamide biosynthetic pathway is a by-product of the RNA world

Journal of Molecular Evolution

Volumn 52, Issue 1, 2001, Pages 73-77

  Cleaves, H James ^a   Miller, Stanley L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biosynthetic pathways; Coenzymes; Evolution of metabolism; Nicotinamide; Quinolinic acid; Semienzymatic synthesis

Indexed keywords

ASPARTIC ACID; DIHYDROXYACETONE PHOSPHATE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINIC ACID; QUINOLINIC ACID; RNA;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CLOSTRIDIUM; COENZYME; ENZYME MECHANISM; MOLECULAR EVOLUTION; NONHUMAN; REACTION ANALYSIS;

CLOSTRIDIUM;

EID: 0035144027     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002390010135     Document Type: Article

References (30)

1. Detection of methylglyoxal as a degradation product of DNA and nucleic acid components treated with strong acid
2. Detection of precursors of quinolinic acid in Escherichia coli
3. Clues from present-day biology: The thioester world
4. Chemical evolution of carbohydrate metabolism
5. Prebiotic synthesis of propiolaldehyde and nicotinamide
6. A new function for a common fold: The crystal structure of quinolinic acid phosphoribosyl transferase
7. Chemistry of potentially prebiological natural products
8. Kinetics and mutual isomerization of trioses and their dehydration to methylglyoxal
9. Nicotinamide adenine dinucleotide biosynthesis and pyridine nucleotide cycle metabolism in microbial systems
10. Kynureninase-type enzymes and the evolution of the aerobic tryptophan-to-nicotinamide adenine dinucleotide pathway
11. Speculations on the origins and evolution of photosynthesis
12. Carbon isotope effects on the metal ion catalyzed decarboxylation of oxaloacetate
13. On the evolution of biochemical syntheses
14. Enzyme recruitment in evolution of new function
15. The evolution of metabolic pathways
16. On the origin of metabolic pathways
17. Selective formation of triose from formaldehyde catalyzed by thiazolium salt
18. Evolution of the genetic apparatus
19. Biosynthesis and recycling of NAD
20. The reaction of guanine derivatives with 1,2-dicarbonyl compounds
21. Protein modification by methylglyoxal: Chemical nature and synthetic mechanism of a major fluorescent adduct
22. Chemical structure in relation to biological activities of vitamin B6
23. Preparation of pyridine derivatives from methane, ammonia, and water by high-frequency electric discharge
24. Origin of life in an iron-sulfur world
25. Coenzymes as fossils of an earlier metabolic state
26. The mode of condensation of aspartic acid and dihydroxyacetone phosphate in quinolinate synthesis in Escherichia coli
27. Classification of the Maillard reaction: A conceptual approach
28. On earlier states of the biochemical system
29. To what extent do biochemical pathways mimic prebiotic pathways?