Comparative responses of bronchial rings to mediators of airway hyperreactivity in healthy horses and those affected with summer pasture-associated obstructive pulmonary disease

American Journal of Veterinary Research

Volumn 62, Issue 2, 2001, Pages 259-263

  Venugopal, Changaram S ^a   Moore, Rustin M ^a   Holmes, Earnestine P ^a   Koch, Catherine E ^a   Seahorn, Thomas L ^a,b   Beadle, Ralph E ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b HAGYARD EQUINE MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; HISTAMINE; LEUKOTRIENE D4; NORADRENALIN; PROSTAGLANDIN F2 ALPHA; SEROTONIN; SUBSTANCE P;

AIRWAY DYNAMICS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; BRONCHUS REACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HORSE; MEDIATOR; NONHUMAN; PATHOGENESIS; SUMMER;

ANIMALIA; BRONCHUS; EQUIDAE; EQUUS CABALLUS;

EID: 0035143337     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2001.62.259     Document Type: Article

References (31)

1. Beadle RE. Summer pasture-associated obstructive pulmonary disease. In: Robinson NE, ed. Current therapy in equine mediane. Philadelphia: WB Saunders Co, 1983;512-516.
2. Buechner-Maxwell V. Airway hyperresponsiveness. Equine respiratory disorders. Compend Contin Educ Pract Vet 1993;15:1379-1389.
3. Barnes PJ, Chung KF, Page CP. Inflammatory mediators and asthma. Pharmacol Rev 1988;40:49-84.
4. Stimler NP, O'Flaherty JT. Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues. Am J Pathol 1983;113:75-84.
5. Barnes PJ. A new approach to the treatment of asthma. N Engl J Med 1989;321:1517-1527.
6. Derksen FJ, Robinson NE, Armstrong PJ, et al. Airway reactivity in ponies with recurrent airway obstruction (heaves). J Appl Physiol 1985;58:598-604.
7. Seahorn TL, Beadle RE, McGorum BC, et al. Quantification of antigen-specific antibody concentrations in tracheal lavage fluid of horses with summer pasture-associated obstructive pulmonary disease. Am J Vet Res 1997;58:1408-1411.
8. Venugopalan CS, Beadle RE, Seahorn TL, et al. Responses of guinea pig lung parenchymal strips to tracheobronchial lavage fluid from horses with summer pasture-associated obstructive pulmonary disease. Vet Res Commun 1998;22:493-503.
9. Costa LRR, Seahorn TL, Moore RM, et al. Correlation of clinical score, intrapleural pressure, cytologic findings of bronchoalveolar fluid, and histopathologic lesions of pulmonary tissue in horses with summer pasture-associated obstructive pulmonary disease. Am J Vet Res 2000;61:167-173.
10. Derksen FJ, Robinson NE. Esophageal and intrapleural pressures in the healthy conscious pony. Am J Vet Res 1980;41:1756-1761.
11. Baxter GM, Tackett RL, Moore JN. Reactivity of equine palmar digital arteries and veins to vasodilating agents. Vet Surg 1989;18:221-226.
12. Venugopalan CS, Moore RM, Holmes EP, et al. Biphasic responses of equine colonic vessel rings to vasoactive inflammatory mediators. J Auton Pharmacol 1998;18:231-237.
13. Van Rossum JM. Cumulative dose-response curves II. Technique for the evaluation of drug parameters. Arch Int Pharma codyn Ther 1963;143:199-330.
14. Wang ZW, Yu MF, Robinson NE, et al. Acetylcholine release from airway cholinergic nerves in horses with heaves, an airway obstructive disease. Am J Respir Crit Care Med 1995;151:830-835.
15. Venugopalan CS, Jenkins HJ, Drazen JM. The functional conversion hypothesis: a contributor to exercise-induced asthma. Med Hypotheses 1988;27: 295-301.
16. Ruffolo RR Jr. Review important concepts of receptor theory. J Auton Pharmacol 1982;2:277-294.
17. Robinson NE, Derksen FJ, Olszewski MA, et al. The pathogenesis of chronic obstructive pulmonary disease of horses. Br Vet J 1996;152:283-306.
18. Yu MF, Wang ZW, Robinson NE, et al. Modulation of bronchial smooth muscle function in horses with heaves. J Appl Physiol 1994;77:2149-2154.
19. Broadstone RV, Scott JS, Derksen FJ, et al. Effects of atropine in ponies with recurrent airway obstruction. J Appl Physiol 1988;65:2720-2725.
20. Beech J. Chronic obstructive pulmonary disease. Vet Clin North Am Equine Pract 1991;7:79-91.
21. McGorum BC, Dixon PM, Halliwell REW. Quantification of histamine in plasma and pulmonary fluids from horses with chronic obstructive pulmonary disease, before and after "natural (hay and straw) challenges". Vet Immunol Immunopathol 1993;36:223-237.
22. Gillis CN, Greene NM, Cronau LH, et al. Pulmonary extraction of 5-hydroxytryptamine and norepinephrine before and after cardiopulmonary bypass in man. Circ Res 1972;30:666-674.
23. Broadstone RV, LeBlanc PH, Derksen FJ, et al. In vitro responses of airway smooth muscle from horses with recurrent airway obstruction. Pulm Pharmacol 1991;4:191-202.
24. Hausdorff WP, Caron MG, Lefkowitz RJ. Turning off the signal: desensitation of beta-adrenergic receptor function. FASEB J 1990;4:2881-2889.
25. Olszewski MA, Zhang XY, Robinson NE. Pre-and postjunctional effects of inflammatory mediators in horse airways. Am J Physiol 1999;277:L327-L333.
26. Venugopalan CS, Holmes EP, Kleinow KM. Evidence for serotonin involvement in the NANC excitatory neurotransmission in the channel catfish intestine. J Auton Pharmacol 1995;15:37-48.
27. Venugopalan CS, Holmes EP. Blockade of electrical field stimulation-induced nonadrenergic noncholinergic (NANC) excitatory response of the guinea pig ileum. Res Commun Chem Pathol Pharmacol 1992;78:225-234.
28. Lotvall J, Svedmyr N. Salmeterol: an inhaled beta-2 agonist with prolonged duration of action. Lung 1993;171:249-264.
29. Szentivani A. The beta adrenergic theory of the atopic abnormality in bronchial asthma. J Allergy 1966;42:203-206.
30. Scott JS, Broadstone RV, Derksen FJ, et al. Beta-adrenergic blockade in ponies with recurrent obstructive pulmonary disease. J Appl Physiol 1988;64:2324-2328.
31. Sonea IM, Bowker RM, Robinson NE, et al. Substance P and calcitonin gene-related peptide-like immunoreactive nerve fibers in lungs from adult equids. Am J Vet Res 1994;55:1066-1074.